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dc.contributor.authorSchmaal, L
dc.contributor.authorPozzi, E
dc.contributor.authorHo, TC
dc.contributor.authorvan Velzen, LS
dc.contributor.authorVeer, IM
dc.contributor.authorOpel, N
dc.contributor.authorVan Someren, EJW
dc.contributor.authorHan, LKM
dc.contributor.authorAftanas, L
dc.contributor.authorAleman, A
dc.contributor.authorBaune, BT
dc.contributor.authorBerger, K
dc.contributor.authorBlanken, TF
dc.contributor.authorCapitao, L
dc.contributor.authorCouvy-Duchesne, B
dc.contributor.authorCullen, KR
dc.contributor.authorDannlowski, U
dc.contributor.authorDavey, C
dc.contributor.authorErwin-Grabner, T
dc.contributor.authorEvans, J
dc.contributor.authorFrodl, T
dc.contributor.authorFu, CHY
dc.contributor.authorGodlewska, B
dc.contributor.authorGotlib, IH
dc.contributor.authorGoya-Maldonado, R
dc.contributor.authorGrabe, HJ
dc.contributor.authorGroenewold, NA
dc.contributor.authorGrotegerd, D
dc.contributor.authorGruber, O
dc.contributor.authorGutman, BA
dc.contributor.authorHall, GB
dc.contributor.authorHarrison, BJ
dc.contributor.authorHatton, SN
dc.contributor.authorHermesdorf, M
dc.contributor.authorHickie, IB
dc.contributor.authorHilland, E
dc.contributor.authorIrungu, B
dc.contributor.authorJonassen, R
dc.contributor.authorKelly, S
dc.contributor.authorKircher, T
dc.contributor.authorKlimes-Dougan, B
dc.contributor.authorKrug, A
dc.contributor.authorLandro, NI
dc.contributor.authorLagopoulos, J
dc.contributor.authorLeerssen, J
dc.contributor.authorLi, M
dc.contributor.authorLinden, DEJ
dc.contributor.authorMacMaster, FP
dc.contributor.authorMcIntosh, AM
dc.contributor.authorMehler, DMA
dc.contributor.authorNenadic, I
dc.contributor.authorPenninx, BWJH
dc.contributor.authorPortella, MJ
dc.contributor.authorReneman, L
dc.contributor.authorRenteria, ME
dc.contributor.authorSacchet, MD
dc.contributor.authorSaemann, PG
dc.contributor.authorSchrantee, A
dc.contributor.authorSim, K
dc.contributor.authorSoares, JC
dc.contributor.authorStein, DJ
dc.contributor.authorTozzi, L
dc.contributor.authorvan Der Wee, NJA
dc.contributor.authorvan Tol, M-J
dc.contributor.authorVermeiren, R
dc.contributor.authorVives-Gilabert, Y
dc.contributor.authorWalter, H
dc.contributor.authorWalter, M
dc.contributor.authorWhalley, HC
dc.contributor.authorWittfeld, K
dc.contributor.authorWhittle, S
dc.contributor.authorWright, MJ
dc.contributor.authorYang, TT
dc.contributor.authorZarate, C
dc.contributor.authorThomopoulos, SI
dc.contributor.authorJahanshad, N
dc.contributor.authorThompson, PM
dc.contributor.authorVeltman, DJ
dc.date.accessioned2020-11-26T23:01:05Z
dc.date.available2020-11-26T23:01:05Z
dc.date.issued2020-05-29
dc.identifierpii: 10.1038/s41398-020-0842-6
dc.identifier.citationSchmaal, L., Pozzi, E., Ho, T. C., van Velzen, L. S., Veer, I. M., Opel, N., Van Someren, E. J. W., Han, L. K. M., Aftanas, L., Aleman, A., Baune, B. T., Berger, K., Blanken, T. F., Capitao, L., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C., Erwin-Grabner, T. ,... Veltman, D. J. (2020). ENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing. TRANSLATIONAL PSYCHIATRY, 10 (1), https://doi.org/10.1038/s41398-020-0842-6.
dc.identifier.issn2158-3188
dc.identifier.urihttp://hdl.handle.net/11343/252075
dc.description.abstractA key objective in the field of translational psychiatry over the past few decades has been to identify the brain correlates of major depressive disorder (MDD). Identifying measurable indicators of brain processes associated with MDD could facilitate the detection of individuals at risk, and the development of novel treatments, the monitoring of treatment effects, and predicting who might benefit most from treatments that target specific brain mechanisms. However, despite intensive neuroimaging research towards this effort, underpowered studies and a lack of reproducible findings have hindered progress. Here, we discuss the work of the ENIGMA Major Depressive Disorder (MDD) Consortium, which was established to address issues of poor replication, unreliable results, and overestimation of effect sizes in previous studies. The ENIGMA MDD Consortium currently includes data from 45 MDD study cohorts from 14 countries across six continents. The primary aim of ENIGMA MDD is to identify structural and functional brain alterations associated with MDD that can be reliably detected and replicated across cohorts worldwide. A secondary goal is to investigate how demographic, genetic, clinical, psychological, and environmental factors affect these associations. In this review, we summarize findings of the ENIGMA MDD disease working group to date and discuss future directions. We also highlight the challenges and benefits of large-scale data sharing for mental health research.
dc.languageEnglish
dc.publisherNATURE PUBLISHING GROUP
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleENIGMA MDD: seven years of global neuroimaging studies of major depression through worldwide data sharing
dc.typeJournal Article
dc.identifier.doi10.1038/s41398-020-0842-6
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titleTranslational Psychiatry
melbourne.source.volume10
melbourne.source.issue1
melbourne.identifier.nhmrc1140764
dc.rights.licenseCC BY
melbourne.elementsid1451592
melbourne.contributor.authorDavey, Christopher
melbourne.contributor.authorWhittle, Sarah
melbourne.contributor.authorHarrison, Benjamin
melbourne.contributor.authorSchmaal, Lianne
melbourne.contributor.authorvan Velzen, Laura
melbourne.contributor.authorBaune, Bernhard
melbourne.contributor.authorPozzi, Elena
dc.identifier.eissn2158-3188
melbourne.identifier.fundernameidNHMRC, 1140764
melbourne.identifier.fundernameidNATIONAL INSTITUTE OF HEALTH, R01MH117601 / 108606875
melbourne.accessrightsOpen Access


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