Fluctuation X-ray diffraction reveals three-dimensional nanostructure and disorder in self-assembled lipid phases
AuthorMartin, AV; Kozlov, A; Berntsen, P; Roque, FG; Flueckiger, L; Saha, S; Greaves, TL; Conn, CE; Hawley, AM; Ryan, TM; ...
Source TitleCommunications Materials
PublisherNature Publishing Group
AffiliationSchool of Physics
Document TypeJournal Article
CitationsMartin, A. V., Kozlov, A., Berntsen, P., Roque, F. G., Flueckiger, L., Saha, S., Greaves, T. L., Conn, C. E., Hawley, A. M., Ryan, T. M., Abbey, B. & Darmanin, C. (2020). Fluctuation X-ray diffraction reveals three-dimensional nanostructure and disorder in self-assembled lipid phases. COMMUNICATIONS MATERIALS, 1 (1), https://doi.org/10.1038/s43246-020-0044-z.
Access StatusOpen Access
Emergent nanoscale order in materials such as self-assembled lipid phases, colloidal materials and metal-organic frameworks is often characterized by small-angle X-ray scattering (SAXS). Frequently, residual disorder in these materials prevents high-resolution 3D structural characterization. Here we demonstrate that angular intensity variations in SAXS patterns can provide previously inaccessible information about local 3D structure via a rich, real-space distribution of three- and four-body statistics. We present the many-body characterisation of a monoolein-based hexagonal phase doped with a phospholipid, revealing non-uniform curvature in the lipid channels, likely due to phase separation of the lipids in the membrane. Our many-body technique has general applicability to nanomaterials with order in the range 10 nm−1 μm currently targeted by synchrotron SAXS and has the potential to impact diverse research areas within chemistry, biology and materials science.
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