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    Neuro-Oncology and Radiogenomics: Time to Integrate?

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    Author
    Lasocki, A; Rosenthal, MA; Roberts-Thomson, SJ; Neal, A; Drummond, KJ
    Date
    2020-11-01
    Source Title
    American Journal of Neuroradiology
    Publisher
    AMER SOC NEURORADIOLOGY
    University of Melbourne Author/s
    Drummond, Katharine; Neal, Andrew; Lasocki, Arian; ROSENTHAL, MARK
    Affiliation
    Surgery (RMH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Lasocki, A., Rosenthal, M. A., Roberts-Thomson, S. J., Neal, A. & Drummond, K. J. (2020). Neuro-Oncology and Radiogenomics: Time to Integrate?. AMERICAN JOURNAL OF NEURORADIOLOGY, 41 (11), pp.1982-1988. https://doi.org/10.3174/ajnr.A6769.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252180
    DOI
    10.3174/ajnr.A6769
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658841
    Abstract
    Radiogenomics aims to predict genetic markers based on imaging features. The critical importance of molecular markers in the diagnosis and management of intracranial gliomas has led to a rapid growth in radiogenomics research, with progressively increasing complexity. Despite the advances in the techniques being examined, there has been little translation into the clinical domain. This has resulted in a growing disconnect between cutting-edge research and assimilation into clinical practice, though the fundamental goal is for these techniques to improve patient care. The goal of this review, therefore, is to discuss possible clinical scenarios in which the addition of radiogenomics may aid patient management. This includes facilitating patient counseling, determining optimal patient management when complete molecular characterization is not possible, reclassifying tumors, and overcoming some of the limitations of histologic assessment. The review also discusses considerations for selecting relevant radiogenomic features based on the clinical setting.

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