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    Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis.

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    Author
    Catalan, A; Tognin, S; Kempton, MJ; Stahl, D; Salazar de Pablo, G; Nelson, B; Pantelis, C; Riecher-Rössler, A; Bressan, R; Barrantes-Vidal, N; ...
    Date
    2020-10-06
    Source Title
    Psychological Medicine
    Publisher
    Cambridge University Press (CUP)
    University of Melbourne Author/s
    Nelson, Christopher; Pantelis, Christos
    Affiliation
    Psychiatry
    Centre for Youth Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Catalan, A., Tognin, S., Kempton, M. J., Stahl, D., Salazar de Pablo, G., Nelson, B., Pantelis, C., Riecher-Rössler, A., Bressan, R., Barrantes-Vidal, N., Krebs, M. -O., Nordentoft, M., Ruhrmann, S., Sachs, G., Rutten, B. P. F., van Os, J., de Haan, L., van der Gaag, M., EU-GEI High Risk Study ,... McGuire, P. (2020). Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis.. Psychol Med, pp.1-9. https://doi.org/10.1017/S0033291720003396.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252205
    DOI
    10.1017/S0033291720003396
    Abstract
    BACKGROUND: Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. METHODS: In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. RESULTS: There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ. CONCLUSIONS: In CHR participants, JTC at baseline was associated with adverse functioning at the follow-up. Interventions designed to improve JTC could be beneficial in the CHR population.

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