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dc.contributor.authorCatalan, A
dc.contributor.authorTognin, S
dc.contributor.authorKempton, MJ
dc.contributor.authorStahl, D
dc.contributor.authorSalazar de Pablo, G
dc.contributor.authorNelson, B
dc.contributor.authorPantelis, C
dc.contributor.authorRiecher-Rössler, A
dc.contributor.authorBressan, R
dc.contributor.authorBarrantes-Vidal, N
dc.contributor.authorKrebs, M-O
dc.contributor.authorNordentoft, M
dc.contributor.authorRuhrmann, S
dc.contributor.authorSachs, G
dc.contributor.authorRutten, BPF
dc.contributor.authorvan Os, J
dc.contributor.authorde Haan, L
dc.contributor.authorvan der Gaag, M
dc.contributor.authorEU-GEI High Risk Study
dc.contributor.authorValmaggia, LR
dc.contributor.authorMcGuire, P
dc.date.accessioned2020-11-26T23:22:39Z
dc.date.available2020-11-26T23:22:39Z
dc.date.issued2020-10-06
dc.identifierpii: S0033291720003396
dc.identifier.citationCatalan, A., Tognin, S., Kempton, M. J., Stahl, D., Salazar de Pablo, G., Nelson, B., Pantelis, C., Riecher-Rössler, A., Bressan, R., Barrantes-Vidal, N., Krebs, M. -O., Nordentoft, M., Ruhrmann, S., Sachs, G., Rutten, B. P. F., van Os, J., de Haan, L., van der Gaag, M., EU-GEI High Risk Study ,... McGuire, P. (2020). Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis.. Psychol Med, pp.1-9. https://doi.org/10.1017/S0033291720003396.
dc.identifier.issn0033-2917
dc.identifier.urihttp://hdl.handle.net/11343/252205
dc.description.abstractBACKGROUND: Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. METHODS: In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16.1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. RESULTS: There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8.13, p = 0.012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ. CONCLUSIONS: In CHR participants, JTC at baseline was associated with adverse functioning at the follow-up. Interventions designed to improve JTC could be beneficial in the CHR population.
dc.languageeng
dc.publisherCambridge University Press (CUP)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleRelationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis.
dc.typeJournal Article
dc.identifier.doi10.1017/S0033291720003396
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titlePsychological Medicine
melbourne.source.pages1-9
dc.rights.licensecc-by-nc-nd
melbourne.elementsid1467485
melbourne.contributor.authorNelson, Christopher
melbourne.contributor.authorPantelis, Christos
dc.identifier.eissn1469-8978
melbourne.accessrightsOpen Access


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