University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Microbiology & Immunology
  • Microbiology & Immunology - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Prolonged Outbreak of Multidrug-Resistant Shigella sonnei Harboring bla(CTX-M-27) in Victoria, Australia

    Thumbnail
    Download
    Published version (503.4Kb)

    Citations
    Altmetric
    Author
    Ingle, DJ; Andersson, P; Valcanis, M; Barnden, J; da Silva, AG; Horan, KA; Seemann, T; Easton, M; Williamson, DA; Sherry, NL; ...
    Date
    2020-12-01
    Source Title
    Antimicrobial Agents and Chemotherapy
    Publisher
    AMER SOC MICROBIOLOGY
    University of Melbourne Author/s
    Seemann, Torsten; Valcanis, Mary; Ingle, Danielle; Williamson, Deborah; Sherry, Norelle; Andersson, Patiyan; Howden, Benjamin; Easton, Marion; Horan, Kristy
    Affiliation
    Microbiology and Immunology
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Ingle, D. J., Andersson, P., Valcanis, M., Barnden, J., da Silva, A. G., Horan, K. A., Seemann, T., Easton, M., Williamson, D. A., Sherry, N. L. & Howden, B. P. (2020). Prolonged Outbreak of Multidrug-Resistant Shigella sonnei Harboring bla(CTX-M-27) in Victoria, Australia. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 64 (12), https://doi.org/10.1128/AAC.01518-20.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252211
    DOI
    10.1128/AAC.01518-20
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674062
    Abstract
    In Australia, cases of shigellosis usually occur in returned travelers from regions of shigellosis endemicity or in men who have sex with men. Resistance to multiple antibiotics has significantly increased in Shigella sonnei isolates and represents a significant public health concern. We investigate an outbreak of multidrug-resistant S. sonnei in Victoria, Australia. We undertook whole-genome sequencing of 54 extended-spectrum-beta-lactamase (ESBL)-producing S. sonnei isolates received at the Microbiological Diagnostic Unit Public Health Laboratory between January 2019 and March 2020. The population structure and antimicrobial resistance profiles were identified by genomic analyses, with 73 previously characterized Australian S. sonnei isolates providing context. Epidemiological data, including age and sex of the shigellosis cases, were also collected. There was a significant increase in cases of ESBL S. sonnei from July 2019. Most of the ESBL S. sonnei isolates (65%) fell within a single cluster that was predominantly comprised of male cases that were characterized by the presence of the blaCTX-M-27 gene conferring resistance to extended-spectrum cephalosporins. These isolates were also multidrug resistant, including resistance to azithromycin and co-trimoxazole and reduced susceptibility to ciprofloxacin. Our data uncovered a prolonged clonal outbreak of ESBL S. sonnei infection that was likely first introduced by returned travelers and has subsequently been circulating locally in Australia. The emergence of a local outbreak of ESBL S. sonnei with a multidrug-resistant profile, including reduced susceptibility to ciprofloxacin, represents a significant public health threat.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53183]
    • Microbiology & Immunology - Research Publications [2213]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors