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dc.contributor.authorIngle, DJ
dc.contributor.authorAndersson, P
dc.contributor.authorValcanis, M
dc.contributor.authorBarnden, J
dc.contributor.authorda Silva, AG
dc.contributor.authorHoran, KA
dc.contributor.authorSeemann, T
dc.contributor.authorEaston, M
dc.contributor.authorWilliamson, DA
dc.contributor.authorSherry, NL
dc.contributor.authorHowden, BP
dc.date.accessioned2020-11-26T23:23:44Z
dc.date.available2020-11-26T23:23:44Z
dc.date.issued2020-12-01
dc.identifierpii: AAC.01518-20
dc.identifier.citationIngle, D. J., Andersson, P., Valcanis, M., Barnden, J., da Silva, A. G., Horan, K. A., Seemann, T., Easton, M., Williamson, D. A., Sherry, N. L. & Howden, B. P. (2020). Prolonged Outbreak of Multidrug-Resistant Shigella sonnei Harboring bla(CTX-M-27) in Victoria, Australia. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 64 (12), https://doi.org/10.1128/AAC.01518-20.
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/11343/252211
dc.description.abstractIn Australia, cases of shigellosis usually occur in returned travelers from regions of shigellosis endemicity or in men who have sex with men. Resistance to multiple antibiotics has significantly increased in Shigella sonnei isolates and represents a significant public health concern. We investigate an outbreak of multidrug-resistant S. sonnei in Victoria, Australia. We undertook whole-genome sequencing of 54 extended-spectrum-beta-lactamase (ESBL)-producing S. sonnei isolates received at the Microbiological Diagnostic Unit Public Health Laboratory between January 2019 and March 2020. The population structure and antimicrobial resistance profiles were identified by genomic analyses, with 73 previously characterized Australian S. sonnei isolates providing context. Epidemiological data, including age and sex of the shigellosis cases, were also collected. There was a significant increase in cases of ESBL S. sonnei from July 2019. Most of the ESBL S. sonnei isolates (65%) fell within a single cluster that was predominantly comprised of male cases that were characterized by the presence of the bla CTX-M-27 gene conferring resistance to extended-spectrum cephalosporins. These isolates were also multidrug resistant, including resistance to azithromycin and co-trimoxazole and reduced susceptibility to ciprofloxacin. Our data uncovered a prolonged clonal outbreak of ESBL S. sonnei infection that was likely first introduced by returned travelers and has subsequently been circulating locally in Australia. The emergence of a local outbreak of ESBL S. sonnei with a multidrug-resistant profile, including reduced susceptibility to ciprofloxacin, represents a significant public health threat.
dc.languageEnglish
dc.publisherAMER SOC MICROBIOLOGY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleProlonged Outbreak of Multidrug-Resistant Shigella sonnei Harboring bla(CTX-M-27) in Victoria, Australia
dc.typeJournal Article
dc.identifier.doi10.1128/AAC.01518-20
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleAntimicrobial Agents and Chemotherapy
melbourne.source.volume64
melbourne.source.issue12
melbourne.identifier.nhmrc1105905
melbourne.identifier.nhmrc1149991
dc.rights.licenseCC BY
melbourne.elementsid1467833
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674062
melbourne.contributor.authorSeemann, Torsten
melbourne.contributor.authorValcanis, Mary
melbourne.contributor.authorIngle, Danielle
melbourne.contributor.authorWilliamson, Deborah
melbourne.contributor.authorSherry, Norelle
melbourne.contributor.authorAndersson, Patiyan
melbourne.contributor.authorHowden, Benjamin
melbourne.contributor.authorEaston, Marion
melbourne.contributor.authorHoran, Kristy
dc.identifier.eissn1098-6596
melbourne.identifier.fundernameidNHMRC, 1105905
melbourne.identifier.fundernameidNHMRC, 1149991
melbourne.accessrightsOpen Access


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