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dc.contributor.authorVidhyavathi, V
dc.contributor.authorIqbal, HS
dc.contributor.authorKanthamani, K
dc.contributor.authorSolomon, SS
dc.contributor.authorNandagopal, P
dc.contributor.authorLuchters, S
dc.contributor.authorPham, MD
dc.contributor.authorForbes, J
dc.contributor.authorCrowe, SM
dc.contributor.authorMcMurran, C
dc.contributor.authorAnderson, DA
dc.contributor.authorBalakrishnan, P
dc.date.accessioned2020-11-26T23:24:19Z
dc.date.available2020-11-26T23:24:19Z
dc.date.issued2020-09-01
dc.identifier.citationVidhyavathi, V., Iqbal, H. S., Kanthamani, K., Solomon, S. S., Nandagopal, P., Luchters, S., Pham, M. D., Forbes, J., Crowe, S. M., McMurran, C., Anderson, D. A. & Balakrishnan, P. (2020). Performance characteristics of an instrument-free point-of-care CD4 test (VISITECT (R) CD4) for use in resource-limited settings. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 48 (9), https://doi.org/10.1177/0300060520955028.
dc.identifier.issn0300-0605
dc.identifier.urihttp://hdl.handle.net/11343/252214
dc.description.abstractOBJECTIVE: CD4+ T lymphocyte count remains the most common biomarker of immune status and disease progression in human immunodeficiency virus (HIV)-positive individuals. VISITECT®CD4 is an instrument-free, low-cost point-of-care CD4 test with a cut-off of 350 CD4 cells/μL. This study aimed to evaluate VISITECT®CD4 test's diagnostic accuracy. METHODS: Two hundred HIV-positive patients attending a tertiary HIV centre in South India were recruited. Patients provided venous blood for reference and VISITECT®CD4 tests. An additional finger-prick blood sample was obtained for VISITECT®CD4. VISITECT®CD4's diagnostic performance in identifying individuals with CD4 counts ≤350 cells/μL was assessed by calculating sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) taking flow cytometry as the reference. RESULTS: The overall agreement between VISITECT®CD4 and flow cytometry was 89.5% using venous blood and 81.5% using finger-prick blood. VISITECT®CD4 showed better performance using venous blood [sensitivity: 96.6% (95% confidence interval: 92.1%-98.9%), specificity: 70.9% (57.1%-82.4%), PPV: 89.7% (83.9%-94.0%) and NPV: 88.6% (75.4%-96.2%)] than using finger-prick blood [sensitivity: 84.8% (77.9%-90.2%), specificity: 72.7% (59.0%-83.9%), PPV: 89.1% (82.7%-93.8%) and NPV: 64.5% (51.3%-76.3%)]. CONCLUSION: VISITECT®CD4 performed well using venous blood, demonstrating its potential utility in decentralization of CD4 testing services in resource-constrained settings.
dc.languageEnglish
dc.publisherSAGE PUBLICATIONS LTD
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titlePerformance characteristics of an instrument-free point-of-care CD4 test (VISITECT (R) CD4) for use in resource-limited settings
dc.typeJournal Article
dc.identifier.doi10.1177/0300060520955028
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleJournal of International Medical Research
melbourne.source.volume48
melbourne.source.issue9
dc.rights.licenseCC BY-NC
melbourne.elementsid1467879
melbourne.contributor.authorAnderson, David
dc.identifier.eissn1473-2300
melbourne.accessrightsOpen Access


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