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    Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?

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    Author
    Spiegel, JL; Jakob, M; Kruizenga, M; Freytag, S; Bertlich, M; Canis, M; Ihler, F; Haubner, F; Kitz, J; Weiss, BG
    Date
    2020-10-03
    Source Title
    European Archives of Oto-Rhino-Laryngology
    Publisher
    Springer Science and Business Media LLC
    University of Melbourne Author/s
    Freytag, Saskia
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Spiegel, J. L., Jakob, M., Kruizenga, M., Freytag, S., Bertlich, M., Canis, M., Ihler, F., Haubner, F., Kitz, J. & Weiss, B. G. (2020). Cancer stem cell markers in adenocarcinoma of the salivary glands - reliable prognostic markers?. Eur Arch Otorhinolaryngol, pp.1-12. https://doi.org/10.1007/s00405-020-06389-7.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252219
    DOI
    10.1007/s00405-020-06389-7
    Abstract
    PURPOSE: Adenocarcinoma of the salivary glands is of low incidence and a broad range of histopathological subtypes. Cancer stem cell markers (CSC) might serve as novel prognostic parameters. To date, only a few studies examined the expression of CSC in adenocarcinoma of the salivary glands with diverging results. To further investigate the reliability in terms of prognostic value, a histopathological analysis of CSCs on a cohort of patients with adenocarcinomas of the major salivary glands was performed. METHODS: Tumor samples of 40 consecutive patients with adenocarcinoma of the major salivary gland treated with curative intend at one tertiary center were stained with the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2. Expression of these markers was correlated with clinicopathological parameters and survival estimates. RESULTS: Correlation of high expression of ALDH1 with higher grading (p < 0.001) and high expression of CD44 with the localization of the neoplasm (p = 0.05), larger tumor size (p = 0.006), positive pN-category (p = 0.023), and advanced UICC stage (p = 0.002) was found. Furthermore, high expression of SOX2 correlated with a negative perineural invasion (p = 0.02). No significant correlation of any investigated marker with survival estimates was observed. CONCLUSION: In conclusion, our study did not find a significant correlation of the investigated CSCs with survival estimates in adenocarcinoma of the major salivary glands. Recapitulating the results of our study in conjunction with data in the literature, the CSCs ALDH1, BMI-1, CD44, Nanog, and SOX2 do not seem to serve as reliable prognostic parameters in the treatment of adenocarcinoma of the salivary glands.

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