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dc.contributor.authorHua, X
dc.contributor.authorGray, A
dc.contributor.authorWolstenholme, J
dc.contributor.authorClarke, P
dc.contributor.authorMolyneux, AJ
dc.contributor.authorKerr, RSC
dc.contributor.authorClarke, A
dc.contributor.authorSneade, M
dc.contributor.authorRivero-Arias, O
dc.date.accessioned2020-11-26T23:29:24Z
dc.date.available2020-11-26T23:29:24Z
dc.date.issued2021-02-01
dc.identifierpii: 5930280
dc.identifier.citationHua, X., Gray, A., Wolstenholme, J., Clarke, P., Molyneux, A. J., Kerr, R. S. C., Clarke, A., Sneade, M. & Rivero-Arias, O. (2021). Survival, Dependency, and Health-Related Quality of Life in Patients With Ruptured Intracranial Aneurysm: 10-Year Follow-up of the United Kingdom Cohort of the International Subarachnoid Aneurysm Trial. NEUROSURGERY, 88 (2), pp.252-260. https://doi.org/10.1093/neuros/nyaa454.
dc.identifier.issn0148-396X
dc.identifier.urihttp://hdl.handle.net/11343/252243
dc.description.abstractBACKGROUND: Previous analyses of the International Subarachnoid Aneurysm Trial (ISAT) cohort have reported on clinical outcomes after treatment of a ruptured intracranial aneurysm with either neurosurgical clipping or endovascular coiling. OBJECTIVE: To evaluate the long-term quality-adjusted life years (QALYs) gained of endovascular coiling compare to neurosurgical clipping in the UK cohort of ISAT. METHODS: Between September 12, 1994 and May 1, 2002, patients with ruptured intracranial aneurysms who were assumed treatment equipoise were randomly allocated to either neurosurgical clipping or endovascular coiling. We followed-up 1644 patients in 22 UK neurosurgical centers for a minimum of 10 yr. Health-related quality of life (HRQoL) was collected through yearly questionnaires, measured by utilities calculated from the EQ-5D-3L. We compared HRQoL between the 2 treatment groups over a period of 10 yr. In all, 1-yr, 5-yr, and 10-yr QALYs were estimated by combining utility and survival information. RESULTS: Higher average utility values were found in the endovascular group throughout the follow-up period, with mean differences between groups statistically significant in most years. The 10-yr QALYs were estimated to be 6.68 (95% CI: 6.45-6.90) in the coiling group and 6.32 (95% CI: 6.10-6.55) in the clipping group, respectively, a significant mean difference of 0.36 (95% CI: 0.04-0.66). A third of this mean QALYs gain was estimated to derive solely from HRQoL differences. CONCLUSION: HRQoL after treatment of a ruptured intracranial aneurysm was better after endovascular coiling compared to neurosurgical clipping, which contributed significantly to the QALYs gained over a 10-yr period.
dc.languageEnglish
dc.publisherOXFORD UNIV PRESS INC
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleSurvival, Dependency, and Health-Related Quality of Life in Patients With Ruptured Intracranial Aneurysm: 10-Year Follow-up of the United Kingdom Cohort of the International Subarachnoid Aneurysm Trial
dc.typeJournal Article
dc.identifier.doi10.1093/neuros/nyaa454
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleNeurosurgery
melbourne.source.volume88
melbourne.source.issue2
melbourne.source.pages252-260
dc.rights.licenseCC BY
melbourne.elementsid1469535
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7803435
melbourne.contributor.authorHua, Xinyang
melbourne.contributor.authorClarke, Philip
dc.identifier.eissn1524-4040
melbourne.accessrightsOpen Access


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