University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Engineering
  • Biomedical Engineering
  • Biomedical Engineering - Research Publications
  • View Item
  • Minerva Access
  • Engineering
  • Biomedical Engineering
  • Biomedical Engineering - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience.

    Thumbnail
    Download
    Published version (1.053Mb)

    Citations
    Scopus
    Altmetric
    1
    Author
    Oxley, TJ; Yoo, PE; Rind, GS; Ronayne, SM; Lee, CMS; Bird, C; Hampshire, V; Sharma, RP; Morokoff, A; Williams, DL; ...
    Date
    2020-10-28
    Source Title
    Journal of NeuroInterventional Surgery
    Publisher
    BMJ
    University of Melbourne Author/s
    Burkitt, Anthony; Grayden, David; Oxley, Thomas; O'Brien, Terence; May, Clive; Morokoff, Andrew; Rind, Gil; Opie, Nicholas; Desmond, Patricia; Campbell, Bruce; ...
    Affiliation
    Biomedical Engineering
    Medicine and Radiology
    Surgery (RMH)
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Oxley, T. J., Yoo, P. E., Rind, G. S., Ronayne, S. M., Lee, C. M. S., Bird, C., Hampshire, V., Sharma, R. P., Morokoff, A., Williams, D. L., MacIsaac, C., Howard, M. E., Irving, L., Vrljic, I., Williams, C., John, S. E., Weissenborn, F., Dazenko, M., Balabanski, A. H. ,... Opie, N. L. (2020). Motor neuroprosthesis implanted with neurointerventional surgery improves capacity for activities of daily living tasks in severe paralysis: first in-human experience.. J Neurointerv Surg, pp.neurintsurg-2020-016862-. https://doi.org/10.1136/neurintsurg-2020-016862.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252257
    DOI
    10.1136/neurintsurg-2020-016862
    NHMRC Grant code
    NHMRC/1062532
    Abstract
    BACKGROUND: Implantable brain-computer interfaces (BCIs), functioning as motor neuroprostheses, have the potential to restore voluntary motor impulses to control digital devices and improve functional independence in patients with severe paralysis due to brain, spinal cord, peripheral nerve or muscle dysfunction. However, reports to date have had limited clinical translation. METHODS: Two participants with amyotrophic lateral sclerosis (ALS) underwent implant in a single-arm, open-label, prospective, early feasibility study. Using a minimally invasive neurointervention procedure, a novel endovascular Stentrode BCI was implanted in the superior sagittal sinus adjacent to primary motor cortex. The participants undertook machine-learning-assisted training to use wirelessly transmitted electrocorticography signal associated with attempted movements to control multiple mouse-click actions, including zoom and left-click. Used in combination with an eye-tracker for cursor navigation, participants achieved Windows 10 operating system control to conduct instrumental activities of daily living (IADL) tasks. RESULTS: Unsupervised home use commenced from day 86 onwards for participant 1, and day 71 for participant 2. Participant 1 achieved a typing task average click selection accuracy of 92.63% (100.00%, 87.50%-100.00%) (trial mean (median, Q1-Q3)) at a rate of 13.81 (13.44, 10.96-16.09) correct characters per minute (CCPM) with predictive text disabled. Participant 2 achieved an average click selection accuracy of 93.18% (100.00%, 88.19%-100.00%) at 20.10 (17.73, 12.27-26.50) CCPM. Completion of IADL tasks including text messaging, online shopping and managing finances independently was demonstrated in both participants. CONCLUSION: We describe the first-in-human experience of a minimally invasive, fully implanted, wireless, ambulatory motor neuroprosthesis using an endovascular stent-electrode array to transmit electrocorticography signals from the motor cortex for multiple command control of digital devices in two participants with flaccid upper limb paralysis.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45770]
    • Surgery (RMH) - Research Publications [264]
    • Medicine and Radiology - Research Publications [2347]
    • Biomedical Engineering - Research Publications [148]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors