Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease
AuthorHuynh, K; Lim, WLF; Giles, C; Jayawardana, KS; Salim, A; Mellett, NA; Smith, AAT; Olshansky, G; Drew, BG; Chatterjee, P; ...
Source TitleNature Communications
University of Melbourne Author/sAmes, David; Masters, Colin; Meikle, Peter; Bush, Ashley; Rowe, Christopher; Villemagne, Victor; Salim, Agus; Huynh, Kevin; Smith, Adam; Giles, Corey
Florey Department of Neuroscience and Mental Health
Medicine and Radiology
Melbourne School of Population and Global Health
Document TypeJournal Article
CitationsHuynh, K., Lim, W. L. F., Giles, C., Jayawardana, K. S., Salim, A., Mellett, N. A., Smith, A. A. T., Olshansky, G., Drew, B. G., Chatterjee, P., Martins, I., Laws, S. M., Bush, A. I., Rowe, C. C., Villemagne, V. L., Ames, D., Masters, C. L., Arnold, M., Nho, K. ,... Meikle, P. J. (2020). Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease. NATURE COMMUNICATIONS, 11 (1), https://doi.org/10.1038/s41467-020-19473-7.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655942
Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM3 gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerides). We subsequently identified similar lipid signatures in both cohorts with future disease. Lastly, we developed multivariate lipid models that improved classification and prediction. Our results provide a holistic view between the lipidome and AD using a comprehensive approach, providing targets for further mechanistic investigation.
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