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dc.contributor.authorHuynh, K
dc.contributor.authorLim, WLF
dc.contributor.authorGiles, C
dc.contributor.authorJayawardana, KS
dc.contributor.authorSalim, A
dc.contributor.authorMellett, NA
dc.contributor.authorSmith, AAT
dc.contributor.authorOlshansky, G
dc.contributor.authorDrew, BG
dc.contributor.authorChatterjee, P
dc.contributor.authorMartins, I
dc.contributor.authorLaws, SM
dc.contributor.authorBush, AI
dc.contributor.authorRowe, CC
dc.contributor.authorVillemagne, VL
dc.contributor.authorAmes, D
dc.contributor.authorMasters, CL
dc.contributor.authorArnold, M
dc.contributor.authorNho, K
dc.contributor.authorSaykin, AJ
dc.contributor.authorBaillie, R
dc.contributor.authorHan, X
dc.contributor.authorKaddurah-Daouk, R
dc.contributor.authorMartins, RN
dc.contributor.authorMeikle, PJ
dc.date.accessioned2020-11-26T23:33:43Z
dc.date.available2020-11-26T23:33:43Z
dc.date.issued2020-11-10
dc.identifierpii: 10.1038/s41467-020-19473-7
dc.identifier.citationHuynh, K., Lim, W. L. F., Giles, C., Jayawardana, K. S., Salim, A., Mellett, N. A., Smith, A. A. T., Olshansky, G., Drew, B. G., Chatterjee, P., Martins, I., Laws, S. M., Bush, A. I., Rowe, C. C., Villemagne, V. L., Ames, D., Masters, C. L., Arnold, M., Nho, K. ,... Meikle, P. J. (2020). Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease. NATURE COMMUNICATIONS, 11 (1), https://doi.org/10.1038/s41467-020-19473-7.
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/11343/252269
dc.description.abstractChanges to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisation. In this study we examined peripheral samples of two cohorts (AIBL, n = 1112 and ADNI, n = 800). We are able to identify concordant peripheral signatures associated with prevalent AD arising from lipid pathways including; ether lipids, sphingolipids (notably GM3 gangliosides) and lipid classes previously associated with cardiometabolic disease (phosphatidylethanolamine and triglycerides). We subsequently identified similar lipid signatures in both cohorts with future disease. Lastly, we developed multivariate lipid models that improved classification and prediction. Our results provide a holistic view between the lipidome and AD using a comprehensive approach, providing targets for further mechanistic investigation.
dc.languageEnglish
dc.publisherNATURE RESEARCH
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleConcordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease
dc.typeJournal Article
dc.identifier.doi10.1038/s41467-020-19473-7
melbourne.affiliation.departmentFlorey Department of Neuroscience and Mental Health
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentMedicine (Austin & Northern Health)
melbourne.affiliation.departmentPsychiatry
melbourne.affiliation.departmentMelbourne Medical School
melbourne.affiliation.facultyMedicine, Dentistry & Health Sciences
melbourne.source.titleNature Communications
melbourne.source.volume11
melbourne.source.issue1
melbourne.source.pages5698-
dc.rights.licenseCC BY
melbourne.elementsid1479532
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7655942
melbourne.contributor.authorAmes, David
melbourne.contributor.authorMasters, Colin
melbourne.contributor.authorMeikle, Peter
melbourne.contributor.authorBush, Ashley
melbourne.contributor.authorRowe, Christopher
melbourne.contributor.authorVillemagne, Victor
melbourne.contributor.authorSalim, Agus
melbourne.contributor.authorHuynh, Kevin
melbourne.contributor.authorSmith, Adam
melbourne.contributor.authorGiles, Corey
dc.identifier.eissn2041-1723
melbourne.accessrightsOpen Access


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