Show simple item record

dc.contributor.authorCox, IA
dc.contributor.authorArriagada, NB
dc.contributor.authorde Graaff, B
dc.contributor.authorCorte, TJ
dc.contributor.authorGlaspole, I
dc.contributor.authorLartey, S
dc.contributor.authorWalters, EH
dc.contributor.authorPalmer, AJ
dc.date.accessioned2020-11-26T23:33:56Z
dc.date.available2020-11-26T23:33:56Z
dc.date.issued2020-12-31
dc.identifierpii: 29/158/200154
dc.identifier.citationCox, I. A., Arriagada, N. B., de Graaff, B., Corte, T. J., Glaspole, I., Lartey, S., Walters, E. H. & Palmer, A. J. (2020). Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis. EUROPEAN RESPIRATORY REVIEW, 29 (158), https://doi.org/10.1183/16000617.0154-2020.
dc.identifier.issn0905-9180
dc.identifier.urihttp://hdl.handle.net/11343/252270
dc.description.abstractIdiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease presenting in persons 50 years and older. Through a comprehensive review of available studies, we aimed to assess health-related quality of life (HRQoL) of people living with IPF and the instruments used in this assessment.Searches were conducted up to May, 2020. Quality appraisal and data extraction were performed using pre-designed forms. Narrative synthesis approach was used to report results of the systematic review and a random effects model was used for the meta-analysis. A leave-one-out sensitivity analysis was performed, and a trim and fill method was used to assess publication bias.The review included 134 studies. The most used instruments to measure HRQoL were St George's Respiratory Questionnaire (SGRQ), Short Form 36 (SF36) and EuroQoL (EQ5D). Standardised mean scores (95% confidence interval) for these instruments were as follows: SGRQ total score: 44.72 (42.21-47.22); SF36 physical component score (PCS): 37.00 (34.74-39.26) SF36 mental component score (MCS): 50.18 (48.41-51.95); King's Brief Interstitial Lung Disease questionnaire total score: 58.38 (55.26-61.51); and EQ5D utility: 0.73 (0.68-0.79). Analysis of standardised means for both SGRQ and SF36 demonstrated worse scores in physical health domains as compared to mental health domains.This systematic review confirms that IPF negatively affected HRQoL, mostly impacting the physical health domains. This study also demonstrated that a diverse number of instruments are used to evaluate HRQoL. In view of this diversity, a standardised approach to measurement of HRQoL for IPF is important to ensure that comparisons made are reliable.
dc.languageEnglish
dc.publisherEUROPEAN RESPIRATORY SOC JOURNALS LTD
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.titleHealth-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis
dc.typeJournal Article
dc.identifier.doi10.1183/16000617.0154-2020
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.source.titleEuropean Respiratory Review
melbourne.source.volume29
melbourne.source.issue158
melbourne.source.pages1-22
dc.rights.licensecc-by-nc
melbourne.elementsid1479576
melbourne.contributor.authorPalmer, Andrew
dc.identifier.eissn1600-0617
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record