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    Total Antioxidant Capacity and Frailty in Older Men

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    Author
    Tembo, MC; Holloway-Kew, KL; Bortolasci, CC; Sui, SX; Brennan-Olsen, SL; Williams, LJ; Kotowicz, MA; Pasco, JA
    Date
    2020-09-01
    Source Title
    American Journal of Men's Health
    Publisher
    SAGE PUBLICATIONS INC
    University of Melbourne Author/s
    Pasco, Julie; Brennan-Olsen, Sharon; Kotowicz, Mark
    Affiliation
    Medicine and Radiology
    Metadata
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    Document Type
    Conference Paper
    Citations
    Tembo, M. C., Holloway-Kew, K. L., Bortolasci, C. C., Sui, S. X., Brennan-Olsen, S. L., Williams, L. J., Kotowicz, M. A. & Pasco, J. A. (2020). Total Antioxidant Capacity and Frailty in Older Men. AMERICAN JOURNAL OF MENS HEALTH, 14, (5), SAGE PUBLICATIONS INC. https://doi.org/10.1177/1557988320946592.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252279
    DOI
    10.1177/1557988320946592
    Abstract
    Frailty, a clinical syndrome characterized by multisystem dysregulation, has been associated with high levels of oxidative stress. We investigated the association between serum total antioxidant capacity (TAC) and frailty in older men. This cross-sectional study included 581 men (age 60-90 years) enrolled in the Geelong Osteoporosis Study. Frailty comprised at least three of unintentional weight loss, exhaustion, low physical activity, slowness, and weakness. Serum TAC was measured by quantitative colorimetric determination and expressed as uric acid equivalents (mM). Relationships between TAC (in <i>SD</i> units) and frailty were explored using multivariable logistic regression models. Sociodemographic, anthropometric, and lifestyle variables were tested as potential confounders and effect modifiers. A sensitivity analysis excluded participants (<i>n</i> = 145) in the upper quartile of TAC, who were likely to have hyperuricemia. Fifty (8.6%) men were frail. There was evidence that higher TAC levels were associated with increased likelihood of frailty (<i>OR</i> 1.34, 95% confidence interval [CI; 0.99, 1.80]), and this was attenuated after adjustment for age and body mass index (BMI; <i>OR</i> 1.26, 95% CI [0.93,1.71]). No effect modifiers or other confounders were identified. The sensitivity analysis revealed a positive association between TAC and frailty, before and after accounting for age and BMI (adjusted <i>OR</i> 1.79, 95% CI [1.01, 3.17] <i>p</i> = .038). These results suggest a positive association between TAC levels and frailty, supporting the hypothesis that this biomarker could be useful in identifying individuals at risk of frailty. We speculate that a milieu of heightened oxidative stress in frailty may elevate the oxidative stress regulatory set point, raising antioxidant activity. This warrants further investigation.

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