The protective potential of Fc-mediated antibody functions against influenza virus and other viral pathogens
Web of Science
AuthorVanderven, HA; Kent, SJ
Source TitleImmunology and Cell Biology
AffiliationMicrobiology and Immunology
Document TypeJournal Article
CitationsVanderven, H. A. & Kent, S. J. (2020). The protective potential of Fc-mediated antibody functions against influenza virus and other viral pathogens. IMMUNOLOGY AND CELL BIOLOGY, 98 (4), pp.253-263. https://doi.org/10.1111/imcb.12312.
Access StatusOpen Access
In recent years, there has been a renewed interest in utilizing antibody fragment crystallizable (Fc) functions to prevent and control viral infections. The protective and therapeutic potential of Fc-mediated antibody functions have been assessed for some clinically important human viruses, including HIV, hemorrhagic fever viruses and influenza virus. There is mounting evidence that influenza-specific antibodies with Fc-mediated functions, such as antibody-dependent cellular cytotoxicity and antibody-dependent phagocytosis, can aid in the clearance of influenza virus infection. Recent influenza challenge studies and intravenous immunoglobulin G therapy studies in humans suggest a protective role for Fc effector functions in vivo. Broadly reactive influenza antibodies with Fc-mediated functions are prevalent in the human population and could inform the development of a universally protective influenza vaccine or therapy. In this review, we explore the utility of antibodies with Fc-mediated effector functions against viral infections with a focus on influenza virus.
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