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dc.contributor.authorMcSharry, BP
dc.contributor.authorSamer, C
dc.contributor.authorMcWilliam, HEG
dc.contributor.authorAshley, CL
dc.contributor.authorYee, MB
dc.contributor.authorSteain, M
dc.contributor.authorLiu, L
dc.contributor.authorFairlie, DP
dc.contributor.authorKinchington, PR
dc.contributor.authorMcCluskey, J
dc.contributor.authorAbendroth, A
dc.contributor.authorVilladangos, JA
dc.contributor.authorRossjohn, J
dc.contributor.authorSlobedman, B
dc.date.accessioned2020-11-27T00:07:04Z
dc.date.available2020-11-27T00:07:04Z
dc.date.issued2020-03-03
dc.identifierpii: S2211-1247(20)30171-6
dc.identifier.citationMcSharry, B. P., Samer, C., McWilliam, H. E. G., Ashley, C. L., Yee, M. B., Steain, M., Liu, L., Fairlie, D. P., Kinchington, P. R., McCluskey, J., Abendroth, A., Villadangos, J. A., Rossjohn, J. & Slobedman, B. (2020). Virus-Mediated Suppression of the Antigen Presentation Molecule MR1. CELL REPORTS, 30 (9), pp.2948-+. https://doi.org/10.1016/j.celrep.2020.02.017.
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/11343/252350
dc.description.abstractThe antigen-presenting molecule MR1 presents microbial metabolites related to vitamin B2 biosynthesis to mucosal-associated invariant T cells (MAIT cells). Although bacteria and fungi drive the MR1 biosynthesis pathway, viruses have not previously been implicated in MR1 expression or its antigen presentation. We demonstrate that several herpesviruses inhibit MR1 cell surface upregulation, including a potent inhibition by herpes simplex virus type 1 (HSV-1). This virus profoundly suppresses MR1 cell surface expression and targets the molecule for proteasomal degradation, whereas ligand-induced cell surface expression of MR1 prior to infection enables MR1 to escape HSV-1-dependent targeting. HSV-1 downregulation of MR1 is dependent on de novo viral gene expression, and we identify the Us3 viral gene product as functioning to target MR1. Furthermore, HSV-1 downregulation of MR1 disrupts MAIT T cell receptor (TCR) activation. Accordingly, virus-mediated targeting of MR1 defines an immunomodulatory strategy that functionally disrupts the MR1-MAIT TCR axis.
dc.languageEnglish
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleVirus-Mediated Suppression of the Antigen Presentation Molecule MR1
dc.typeJournal Article
dc.identifier.doi10.1016/j.celrep.2020.02.017
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentChancellery Research
melbourne.source.titleCell Reports
melbourne.source.volume30
melbourne.source.issue9
melbourne.source.pages2948-+
melbourne.identifier.nhmrc1113293
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1440560
melbourne.contributor.authorMcCluskey, James
melbourne.contributor.authorVilladangos, Jose
melbourne.contributor.authorRossjohn, Jamie
melbourne.contributor.authorMcWilliam, Hamish
dc.identifier.eissn2211-1247
melbourne.identifier.fundernameidNHMRC, 1113293
melbourne.accessrightsOpen Access


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