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dc.contributor.authorGan, L
dc.contributor.authorSun, J
dc.contributor.authorYang, S
dc.contributor.authorZhang, X
dc.contributor.authorChen, W
dc.contributor.authorSun, Y
dc.contributor.authorWu, X
dc.contributor.authorCheng, C
dc.contributor.authorYuan, J
dc.contributor.authorLi, A
dc.contributor.authorCorbett, MA
dc.contributor.authorDixon, MP
dc.contributor.authorThomas, T
dc.contributor.authorVoss, AK
dc.contributor.authorGecz, J
dc.contributor.authorWang, G-Z
dc.contributor.authorBonni, A
dc.contributor.authorLi, Q
dc.contributor.authorHuang, J
dc.date.accessioned2020-11-27T00:08:59Z
dc.date.available2020-11-27T00:08:59Z
dc.date.issued2020-03-17
dc.identifierpii: S2211-1247(20)30259-X
dc.identifier.citationGan, L., Sun, J., Yang, S., Zhang, X., Chen, W., Sun, Y., Wu, X., Cheng, C., Yuan, J., Li, A., Corbett, M. A., Dixon, M. P., Thomas, T., Voss, A. K., Gecz, J., Wang, G. -Z., Bonni, A., Li, Q. & Huang, J. (2020). Chromatin-Binding Protein PHF6 Regulates Activity-Dependent Transcriptional Networks to Promote Hunger Response. CELL REPORTS, 30 (11), pp.3717-+. https://doi.org/10.1016/j.celrep.2020.02.085.
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/11343/252360
dc.description.abstractUnderstanding the mechanisms of activity-dependent gene transcription underlying adaptive behaviors is challenging at neuronal-subtype resolution. Using cell-type specific molecular analysis in agouti-related peptide (AgRP) neurons, we reveal that the profound hunger-induced transcriptional changes greatly depend on plant homeodomain finger protein 6 (PHF6), a transcriptional repressor enriched in AgRP neurons. Loss of PHF6 in the satiated mice results in a hunger-state-shifting transcriptional profile, while hunger fails to further induce a rapid and robust activity-dependent gene transcription in PHF6-deficient AgRP neurons. We reveal that PHF6 binds to the promoters of a subset of immediate-early genes (IEGs) and that this chromatin binding is dynamically regulated by hunger state. Depletion of PHF6 decreases hunger-driven feeding motivation and makes the mice resistant to body weight gain under repetitive fasting-refeeding conditions. Our work identifies a neuronal subtype-specific transcriptional repressor that modulates transcriptional profiles in different nutritional states and enables adaptive eating behavior.
dc.languageEnglish
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleChromatin-Binding Protein PHF6 Regulates Activity-Dependent Transcriptional Networks to Promote Hunger Response
dc.typeJournal Article
dc.identifier.doi10.1016/j.celrep.2020.02.085
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleCell Reports
melbourne.source.volume30
melbourne.source.issue11
melbourne.source.pages3717-+
dc.rights.licensecc-by-nc-nd
melbourne.elementsid1442329
melbourne.contributor.authorVoss, Anne
melbourne.contributor.authorThomas, Timothy
dc.identifier.eissn2211-1247
melbourne.accessrightsOpen Access


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