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dc.contributor.authorKelly, GL
dc.contributor.authorStrasser, A
dc.contributor.editorJacks, T
dc.contributor.editorSawyers, CL
dc.date.accessioned2020-11-27T00:09:18Z
dc.date.available2020-11-27T00:09:18Z
dc.date.issued2020-01-01
dc.identifier.citationKelly, G. L. & Strasser, A. (2020). Toward Targeting Antiapoptotic MCL-1 for Cancer Therapy. Jacks, T (Ed.). Sawyers, CL (Ed.). ANNUAL REVIEW OF CANCER BIOLOGY, VOL 4, 4, pp.299-313. ANNUAL REVIEWS.
dc.identifier.urihttp://hdl.handle.net/11343/252362
dc.description.abstract<jats:p> Apoptosis is critical for embryonic development, tissue homeostasis, and the removal of infected or otherwise dangerous cells. It is controlled by three subgroups of the BCL-2 protein family—the BH3-only proteins that initiate cell death; the effectors of cell killing, BAX and BAK; and the antiapoptotic guardians, including MCL-1 and BCL-2. Defects in apoptosis can promote tumorigenesis and render malignant cells refractory to anticancer therapeutics. Activation of cell death by inhibiting antiapoptotic BCL-2 family members has emerged as an attractive strategy for cancer therapy, with the BCL-2 inhibitor venetoclax leading the way. Large-scale cancer genome analyses have revealed frequent amplification of the locus encoding antiapoptotic MCL-1 in human cancers, and functional studies have shown that MCL-1 is essential for the sustained survival and expansion of many types of tumor cells. Structural analysis and medicinal chemistry have led to the development of three distinct small-molecule inhibitors of MCL-1 that are currently undergoing clinical testing. </jats:p>
dc.languageEnglish
dc.publisherANNUAL REVIEWS
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleToward Targeting Antiapoptotic MCL-1 for Cancer Therapy
dc.typeChapter
dc.identifier.doi10.1146/annurev-cancerbio-030419-033510
melbourne.affiliation.departmentMedical Biology (W.E.H.I.)
melbourne.source.titleANNUAL REVIEW OF CANCER BIOLOGY, VOL 4
melbourne.source.volume4
melbourne.source.pages299-313
dc.rights.licensecc-by
melbourne.elementsid1442743
melbourne.contributor.authorKelly, Gemma
melbourne.contributor.authorStrasser, Andreas
melbourne.accessrightsOpen Access


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