Action plan for hit identification (APHID): KAT6A as a case study

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    Author
    Yi, X; Xue, L; Thomas, T; Baell, JB
    Date
    2020-03-01
    Source Title
    Future Medicinal Chemistry
    Publisher
    FUTURE SCI LTD
    University of Melbourne Author/s
    Thomas, Timothy
    Affiliation
    Medical Biology (W.E.H.I.)
    Metadata
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    Document Type
    Journal Article
    Citations
    Yi, X., Xue, L., Thomas, T. & Baell, J. B. (2020). Action plan for hit identification (APHID): KAT6A as a case study. FUTURE MEDICINAL CHEMISTRY, 12 (5), pp.423-438. https://doi.org/10.4155/fmc-2019-0212.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252365
    DOI
    10.4155/fmc-2019-0212
    Abstract
    Here, we describe our action plan for hit identification (APHID) that guides the process of hit triage, with elimination of less tractable hits and retention of more tractable hits. We exemplify the process with reference to our high-throughput screening (HTS) campaign against the enzyme, KAT6A, that resulted in successful identification of a tractable hit. We hope that APHID could serve as a useful, concise and digestible guide for those involved in HTS and hit triage, especially those that are relatively new to this exciting and continually evolving technology.

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