Action plan for hit identification (APHID): KAT6A as a case study

Download
Author
Yi, X; Xue, L; Thomas, T; Baell, JBDate
2020-03-01Source Title
Future Medicinal ChemistryPublisher
FUTURE SCI LTDUniversity of Melbourne Author/s
Thomas, TimothyAffiliation
Medical Biology (W.E.H.I.)Metadata
Show full item recordDocument Type
Journal ArticleCitations
Yi, X., Xue, L., Thomas, T. & Baell, J. B. (2020). Action plan for hit identification (APHID): KAT6A as a case study. FUTURE MEDICINAL CHEMISTRY, 12 (5), pp.423-438. https://doi.org/10.4155/fmc-2019-0212.Access Status
Open AccessAbstract
Here, we describe our action plan for hit identification (APHID) that guides the process of hit triage, with elimination of less tractable hits and retention of more tractable hits. We exemplify the process with reference to our high-throughput screening (HTS) campaign against the enzyme, KAT6A, that resulted in successful identification of a tractable hit. We hope that APHID could serve as a useful, concise and digestible guide for those involved in HTS and hit triage, especially those that are relatively new to this exciting and continually evolving technology.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References