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dc.contributor.authorDunne, EM
dc.contributor.authorHua, Y
dc.contributor.authorSalaudeen, R
dc.contributor.authorHossain, I
dc.contributor.authorNdiaye, M
dc.contributor.authorOrtika, BD
dc.contributor.authorMulholland, EK
dc.contributor.authorHinds, J
dc.contributor.authorManna, S
dc.contributor.authorMackenzie, GA
dc.contributor.authorSatzke, C
dc.date.accessioned2020-11-27T00:13:54Z
dc.date.available2020-11-27T00:13:54Z
dc.date.issued2020-04-22
dc.identifierpii: 5823762
dc.identifier.citationDunne, E. M., Hua, Y., Salaudeen, R., Hossain, I., Ndiaye, M., Ortika, B. D., Mulholland, E. K., Hinds, J., Manna, S., Mackenzie, G. A. & Satzke, C. (2020). Insights into pneumococcal pneumonia using lung aspirates and nasopharyngeal swabs collected from pneumonia patients in The Gambia.. J Infect Dis, https://doi.org/10.1093/infdis/jiaa186.
dc.identifier.issn0022-1899
dc.identifier.urihttp://hdl.handle.net/11343/252390
dc.description.abstractWe investigated the pathogenesis of pneumococcal pneumonia using clinical specimens collected for pneumonia surveillance in The Gambia. Lung aspirates and nasopharyngeal swabs from 31 patients were examined by culture, qPCR, whole genome sequencing, serotyping, and reverse transcription qPCR. Five lung aspirates cultured pneumococci, with a matching strain identified in the nasopharynx. Three virulence genes including ply (pneumolysin) were upregulated >20-fold in the lung compared with the nasopharynx. Nasopharyngeal pneumococcal density was higher in pediatric pneumonia patients compared with controls (p <0.0001). Findings suggest that changes in pneumococcal gene expression occurring in the lung environment may be important in pathogenesis.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInsights into pneumococcal pneumonia using lung aspirates and nasopharyngeal swabs collected from pneumonia patients in The Gambia.
dc.typeJournal Article
dc.identifier.doi10.1093/infdis/jiaa186
melbourne.affiliation.departmentPaediatrics (RCH)
melbourne.source.titleJournal of Infectious Diseases
dc.rights.licensecc-by
melbourne.elementsid1446344
melbourne.contributor.authorSatzke, Catherine
melbourne.contributor.authorMulholland, Edward
melbourne.contributor.authorDunne, Eileen
melbourne.contributor.authorManna, Salvatore
dc.identifier.eissn1537-6613
melbourne.accessrightsOpen Access


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