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    Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior

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    Author
    Tyebji, S; Hannan, AJ; Tonkin, CJ
    Date
    2020-04-28
    Source Title
    Cell Reports
    Publisher
    CELL PRESS
    University of Melbourne Author/s
    Tonkin, Christopher; Hannan, Anthony
    Affiliation
    Medical Biology (W.E.H.I.)
    Florey Department of Neuroscience and Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Tyebji, S., Hannan, A. J. & Tonkin, C. J. (2020). Pathogenic Infection in Male Mice Changes Sperm Small RNA Profiles and Transgenerationally Alters Offspring Behavior. CELL REPORTS, 31 (4), https://doi.org/10.1016/j.celrep.2020.107573.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252400
    DOI
    10.1016/j.celrep.2020.107573
    Abstract
    Germline epigenetic factors influence transgenerational inheritance of behavioral traits upon changes in experience and environment. Immune activation due to infection can also modulate brain function, but whether this experience can be passed down to offspring remains unknown. Here, we show that infection of the male lineage with the common human parasite Toxoplasma results in transgenerational behavioral changes in offspring in a sex-dependent manner. Small RNA sequencing of sperm reveals significant transcriptional differences of infected animals compared to controls. Zygote microinjection of total small RNA from sperm of infected mice partially recapitulates the behavioral phenotype of naturally born offspring, suggesting an epigenetic mechanism of behavioral inheritance in the first generation. Our results demonstrate that sperm epigenetic factors can contribute to intergenerational inheritance of behavioral changes after pathogenic infection, which could have major public health implications.

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