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dc.contributor.authorWragg, KM
dc.contributor.authorTan, H-X
dc.contributor.authorKristensen, AB
dc.contributor.authorNguyen-Robertson, C
dc.contributor.authorKelleher, AD
dc.contributor.authorParsons, MS
dc.contributor.authorWheatley, AK
dc.contributor.authorBerzins, SP
dc.contributor.authorPellicci, DG
dc.contributor.authorKent, SJ
dc.contributor.authorJuno, JA
dc.date.accessioned2020-11-27T00:23:31Z
dc.date.available2020-11-27T00:23:31Z
dc.date.issued2020-06-16
dc.identifierpii: S2211-1247(20)30753-1
dc.identifier.citationWragg, K. M., Tan, H. -X., Kristensen, A. B., Nguyen-Robertson, C., Kelleher, A. D., Parsons, M. S., Wheatley, A. K., Berzins, S. P., Pellicci, D. G., Kent, S. J. & Juno, J. A. (2020). High CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2(+) T Cell Subset with a MAIT Cell-like Transcriptional Profile. CELL REPORTS, 31 (11), https://doi.org/10.1016/j.celrep.2020.107773.
dc.identifier.issn2211-1247
dc.identifier.urihttp://hdl.handle.net/11343/252446
dc.description.abstractVδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here, we demonstrate that CD26 and CD94 define transcriptionally, phenotypically, and functionally distinct Vδ2+ T cell subsets. Despite distinct antigen specificities, CD26hiCD94lo Vδ2+ cells exhibit substantial similarities to CD26hi mucosal-associated invariant T (MAIT) cells, although CD26- Vδ2+ cells exhibit cytotoxic, effector-like profiles. At birth, the Vδ2+Vγ9+ population is dominated by CD26hiCD94lo cells; during adolescence and adulthood, Vδ2+ cells acquire CD94/NKG2A expression and the relative frequency of the CD26hiCD94lo subset declines. Critically, exposure of the CD26hiCD94lo subset to phosphoantigen in the context of interleukin-23 (IL-23) and CD26 engagement drives the acquisition of a cytotoxic program and concurrent loss of the MAIT cell-like phenotype. The ability to modulate the cytotoxic potential of CD26hiCD94lo Vδ2+ cells, combined with their adenosine-binding capacity, may make them ideal targets for immunotherapeutic expansion and adoptive transfer.
dc.languageEnglish
dc.publisherCELL PRESS
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleHigh CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2(+) T Cell Subset with a MAIT Cell-like Transcriptional Profile
dc.typeJournal Article
dc.identifier.doi10.1016/j.celrep.2020.107773
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentScience
melbourne.source.titleCell Reports
melbourne.source.volume31
melbourne.source.issue11
dc.rights.licensecc-by-nc-nd
melbourne.elementsid1453433
melbourne.contributor.authorWheatley, Adam
melbourne.contributor.authorKent, Stephen
melbourne.contributor.authorPellicci, Daniel
melbourne.contributor.authorBerzins, Stuart
melbourne.contributor.authorNguyen-Robertson, Catriona
melbourne.contributor.authorJuno, Jennifer
melbourne.contributor.authorWragg, Kathleen
melbourne.contributor.authorParsons, Matt
melbourne.contributor.authorKristensen, Anne
melbourne.contributor.authorTan, Hyon Xhi
dc.identifier.eissn2211-1247
melbourne.accessrightsOpen Access


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