University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medicine, Dentistry & Health Sciences Collected Works
  • Medicine, Dentistry & Health Sciences Collected Works - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Medicine, Dentistry & Health Sciences Collected Works
  • Medicine, Dentistry & Health Sciences Collected Works - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    TDM is dead. Long live TCI!

    Thumbnail
    Download
    Published version (244.1Kb)

    Citations
    Scopus
    Altmetric
    2
    Author
    Holford, N; Ma, G; Metz, D
    Date
    2020-07-01
    Source Title
    British Journal of Clinical Pharmacology
    Publisher
    WILEY
    University of Melbourne Author/s
    Metz, David
    Affiliation
    Medicine Dentistry & Health Sciences
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Holford, N., Ma, G. & Metz, D. (2020). TDM is dead. Long live TCI!. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, https://doi.org/10.1111/bcp.14434.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252475
    DOI
    10.1111/bcp.14434
    Abstract
    Twenty years ago, target concentration intervention (TCI) was distinguished from therapeutic drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because of the precision of the approach and the ability to link TCI to principles of pharmacokinetics and pharmacodynamics to predict the dose required by an individual (1). We examine the theory and clinical trial evidence supporting the benefits of TCI over TDM and conclude that in the digital age TDM should be abandoned and replaced by TCI.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [45689]
    • Medicine, Dentistry & Health Sciences Collected Works - Research Publications [578]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors