TDM is dead. Long live TCI!

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Author
Holford, N; Ma, G; Metz, DDate
2020-07-01Source Title
British Journal of Clinical PharmacologyPublisher
WILEYUniversity of Melbourne Author/s
Metz, DavidAffiliation
Medicine Dentistry & Health SciencesMetadata
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Journal ArticleCitations
Holford, N., Ma, G. & Metz, D. (2020). TDM is dead. Long live TCI!. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, https://doi.org/10.1111/bcp.14434.Access Status
Open AccessAbstract
Twenty years ago, target concentration intervention (TCI) was distinguished from therapeutic drug monitoring (TDM). It was proposed that TCI would bring more clinical benefit because of the precision of the approach and the ability to link TCI to principles of pharmacokinetics and pharmacodynamics to predict the dose required by an individual (1). We examine the theory and clinical trial evidence supporting the benefits of TCI over TDM and conclude that in the digital age TDM should be abandoned and replaced by TCI.
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