Show simple item record

dc.contributor.authorHaskali, MB
dc.contributor.authorFarnsworth, AL
dc.contributor.authorRoselt, PD
dc.contributor.authorHutton, CA
dc.date.accessioned2020-11-27T00:30:10Z
dc.date.available2020-11-27T00:30:10Z
dc.date.issued2020-08-01
dc.identifierpii: d0md00140f
dc.identifier.citationHaskali, M. B., Farnsworth, A. L., Roselt, P. D. & Hutton, C. A. (2020). 4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules. RSC MEDICINAL CHEMISTRY, 11 (8), pp.919-922. https://doi.org/10.1039/d0md00140f.
dc.identifier.issn2632-8682
dc.identifier.urihttp://hdl.handle.net/11343/252483
dc.description.abstractIndirect radiolabelling has for a long time been the mainstay strategy for radiofluorination of biomolecules. Acylation of biomolecules through the use of an 18F-labelled activated ester is a standard method for indirect radiolabelling. However, the preparation of 18F-labelled activated esters is typically a complex and multistep procedure. Herein, we describe the use of 4-nitrophenyl (PNP) activated esters to rapidly prepare 18F-labelled acylation synthons in one step. Furthermore, we present a comparative study of PNP activated esters and the commonly utilised 2,3,5,6-tetrafluorphenyl (TFP) activated esters under direct radiofluorination conditions and demonstrate their relative acylation behaviour. We demonstrate the superiority of PNP esters under direct radiofluorination conditions with favourable acylation kinetics.
dc.languageEnglish
dc.publisherROYAL SOC CHEMISTRY
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0
dc.title4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules
dc.typeJournal Article
dc.identifier.doi10.1039/d0md00140f
melbourne.affiliation.departmentSchool of Chemistry
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleRSC Medicinal Chemistry
melbourne.source.volume11
melbourne.source.issue8
melbourne.source.pages919-922
dc.rights.licenseCC BY-NC
melbourne.elementsid1456784
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517343
melbourne.contributor.authorHutton, Craig
melbourne.contributor.authorRoselt, Peter
melbourne.contributor.authorHaskali, Mohammad
dc.identifier.eissn2632-8682
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record