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    The role of hepatitis B surface antibodies in HBV infection, disease and clearance

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    Author
    Warner, N; Locarnini, S; Xu, H
    Date
    2020-05-01
    Source Title
    Future Virology
    Publisher
    FUTURE MEDICINE LTD
    University of Melbourne Author/s
    Locarnini, Stephen; Warner, Nadia; Xu, Hui
    Affiliation
    Microbiology and Immunology
    Doherty Institute
    Metadata
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    Document Type
    Journal Article
    Citations
    Warner, N., Locarnini, S. & Xu, H. (2020). The role of hepatitis B surface antibodies in HBV infection, disease and clearance. FUTURE VIROLOGY, 15 (5), pp.293-306. https://doi.org/10.2217/fvl-2019-0147.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252496
    DOI
    10.2217/fvl-2019-0147
    Abstract
    <jats:p> The clinical sequelae associated with chronic HBV infection is generally regarded as a consequence of an inadequate and inappropriate immune response to active viral replication, predominantly at the T-cell level. However, recent studies on hepatitis B surface antigen (HBsAg)-specific B cells and hepatitis B surface antibody (anti-HB) responses have identified their previously unrecognized role in the pathogenesis of chronic hepatitis B (CHB). These studies have also uncovered novel therapeutic approaches to more effectively target HBsAg loss and seroconversion, an important end point and regarded as a functional cure. Anti-HBs IgG has also been shown to have multiple direct acting antiviral roles with the Fab component directly blocking viral entry, and release while the Fc component has been linked to antibody dependent cellular cytotoxicity. Likewise, the HBsAg-specific B-cell dysfunctionality can be reversed providing new therapeutic opportunities to achieve functional cure in CHB. </jats:p>

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