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dc.contributor.authorWarner, N
dc.contributor.authorLocarnini, S
dc.contributor.authorXu, H
dc.date.accessioned2020-11-27T00:32:35Z
dc.date.available2020-11-27T00:32:35Z
dc.date.issued2020-05-01
dc.identifier.citationWarner, N., Locarnini, S. & Xu, H. (2020). The role of hepatitis B surface antibodies in HBV infection, disease and clearance. FUTURE VIROLOGY, 15 (5), pp.293-306. https://doi.org/10.2217/fvl-2019-0147.
dc.identifier.issn1746-0794
dc.identifier.urihttp://hdl.handle.net/11343/252496
dc.description.abstractThe clinical sequelae associated with chronic HBV infection is generally regarded as a consequence of an inadequate and inappropriate immune response to active viral replication, predominantly at the T-cell level. However, recent studies on hepatitis B surface antigen (HBsAg)-specific B cells and hepatitis B surface antibody (anti-HB) responses have identified their previously unrecognized role in the pathogenesis of chronic hepatitis B (CHB). These studies have also uncovered novel therapeutic approaches to more effectively target HBsAg loss and seroconversion, an important end point and regarded as a functional cure. Anti-HBs IgG has also been shown to have multiple direct acting antiviral roles with the Fab component directly blocking viral entry, and release while the Fc component has been linked to antibody dependent cellular cytotoxicity. Likewise, the HBsAg-specific B-cell dysfunctionality can be reversed providing new therapeutic opportunities to achieve functional cure in CHB.
dc.languageEnglish
dc.publisherFUTURE MEDICINE LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe role of hepatitis B surface antibodies in HBV infection, disease and clearance
dc.typeJournal Article
dc.identifier.doi10.2217/fvl-2019-0147
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.affiliation.departmentDoherty Institute
melbourne.source.titleFuture Virology
melbourne.source.volume15
melbourne.source.issue5
melbourne.source.pages293-306
melbourne.identifier.nhmrc1127538
dc.rights.licensecc-by
melbourne.elementsid1458928
melbourne.contributor.authorLocarnini, Stephen
melbourne.contributor.authorWarner, Nadia
melbourne.contributor.authorXu, Hui
dc.identifier.eissn1746-0808
melbourne.identifier.fundernameidNHMRC, 1127538
melbourne.accessrightsOpen Access


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