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dc.contributor.authorAhadova, A
dc.contributor.authorSeppala, TT
dc.contributor.authorEngel, C
dc.contributor.authorGallon, R
dc.contributor.authorBurn, J
dc.contributor.authorHolinski-Feder, E
dc.contributor.authorSteinke-Lange, V
dc.contributor.authorMoeslein, G
dc.contributor.authorNielsen, M
dc.contributor.authorten Broeke, SW
dc.contributor.authorLaghi, L
dc.contributor.authorDominguez-Valentin, M
dc.contributor.authorCapella, G
dc.contributor.authorMacrae, F
dc.contributor.authorScott, R
dc.contributor.authorHueneburg, R
dc.contributor.authorNattermann, J
dc.contributor.authorHoffmeister, M
dc.contributor.authorBrenner, H
dc.contributor.authorBlaeker, H
dc.contributor.authorDoeberitz, MVK
dc.contributor.authorSampson, JR
dc.contributor.authorVasen, H
dc.contributor.authorMecklin, J-P
dc.contributor.authorMoller, P
dc.contributor.authorKloor, M
dc.date.accessioned2020-11-27T00:33:36Z
dc.date.available2020-11-27T00:33:36Z
dc.date.issued2020-08-03
dc.identifier.citationAhadova, A., Seppala, T. T., Engel, C., Gallon, R., Burn, J., Holinski-Feder, E., Steinke-Lange, V., Moeslein, G., Nielsen, M., ten Broeke, S. W., Laghi, L., Dominguez-Valentin, M., Capella, G., Macrae, F., Scott, R., Hueneburg, R., Nattermann, J., Hoffmeister, M., Brenner, H. ,... Kloor, M. (2020). The "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance. INTERNATIONAL JOURNAL OF CANCER, 148 (4), pp.800-811. https://doi.org/10.1002/ijc.33224.
dc.identifier.issn0020-7136
dc.identifier.urihttp://hdl.handle.net/11343/252503
dc.description.abstractIndividuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleThe "unnatural" history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
dc.typeJournal Article
dc.identifier.doi10.1002/ijc.33224
melbourne.affiliation.departmentMedicine and Radiology
melbourne.source.titleInternational Journal of Cancer
melbourne.source.volume148
melbourne.source.issue4
melbourne.source.pages800-811
dc.rights.licensecc-by-nc-nd
melbourne.elementsid1459099
melbourne.contributor.authorMacrae, Finlay
dc.identifier.eissn1097-0215
melbourne.accessrightsOpen Access


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