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    Retinal Vascular Tortuosity and Diameter Associations with Adiposity and Components of Body Composition

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    Author
    Tapp, RJ; Owen, CG; Barman, SA; Welikala, RA; Foster, PJ; Whincup, PH; Strachan, DP; Rudnicka, AR
    Date
    2020-07-29
    Source Title
    Obesity
    Publisher
    WILEY
    University of Melbourne Author/s
    Tapp, Robyn
    Affiliation
    Melbourne School of Population and Global Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Tapp, R. J., Owen, C. G., Barman, S. A., Welikala, R. A., Foster, P. J., Whincup, P. H., Strachan, D. P. & Rudnicka, A. R. (2020). Retinal Vascular Tortuosity and Diameter Associations with Adiposity and Components of Body Composition. OBESITY, 28 (9), pp.1750-1760. https://doi.org/10.1002/oby.22885.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252513
    DOI
    10.1002/oby.22885
    Abstract
    OBJECTIVE: The aim of this study was to assess whether adiposity or body composition relates to microvascular characteristics of the retina, indicative of cardiometabolic function. METHODS: A fully automated QUARTZ software processed retinal images from 68,550 UK Biobank participants (aged 40-69 years). Differences in retinal vessel diameter and tortuosity with body composition measures from the Tanita analyzer were obtained by using multilevel regression analyses adjusted for age, sex, ethnicity, clinic, smoking, and Townsend deprivation index. RESULTS: Venular tortuosity and diameter increased by approximately 2% (P < 10-300 ) and 0.6 μm (P < 10-6 ), respectively, per SD increase in BMI, waist circumference index, waist-hip ratio, total body fat mass index, and fat-free mass index (FFMI). Venular associations with adiposity persisted after adjustment for FFMI, whereas associations with FFMI were weakened by FMI adjustment. Arteriolar diameter (not tortuosity) narrowing with FFMI was independent of adiposity (-0.6 μm; -0.7 to -0.4 μm per SD increment of FFMI), while adiposity associations with arteriolar diameter were largely nonsignificant after adjustment for FFMI. CONCLUSIONS: This demonstrates, on an unprecedented scale, that venular tortuosity and diameter are more strongly associated with adiposity, whereas arteriolar diameter relates more strongly to fat-free mass. Different attributes of the retinal microvasculature may reflect distinct roles of body composition and fatness on the cardiometabolic system.

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