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dc.contributor.authorKok, DL
dc.contributor.authorWang, A
dc.contributor.authorXu, W
dc.contributor.authorChua, MST
dc.contributor.authorGuminski, A
dc.contributor.authorVeness, M
dc.contributor.authorHowle, J
dc.contributor.authorTothill, R
dc.contributor.authorKichendasse, G
dc.contributor.authorPoulsen, M
dc.contributor.authorSandhu, S
dc.contributor.authorFogarty, G
dc.date.accessioned2020-11-27T00:35:46Z
dc.date.available2020-11-27T00:35:46Z
dc.date.issued2020-08-05
dc.identifier.citationKok, D. L., Wang, A., Xu, W., Chua, M. S. T., Guminski, A., Veness, M., Howle, J., Tothill, R., Kichendasse, G., Poulsen, M., Sandhu, S. & Fogarty, G. (2020). The changing paradigm of managing Merkel cell carcinoma in Australia: An expert commentary. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 16 (6), pp.312-319. https://doi.org/10.1111/ajco.13407.
dc.identifier.issn1743-7555
dc.identifier.urihttp://hdl.handle.net/11343/252517
dc.description.abstractMerkel cell carcinoma (MCC) is a highly aggressive neuroendocrine tumor of the skin with an estimated disease-associated mortality of 15-33%. Australia has a higher incidence of MCC compared to the rest of the world, thought to be due to a higher ultraviolet index. The Australian MCC population is distinct from the MCC population of the Northern hemisphere, characterized by a predominantly viral negative etiology with high tumor mutational burden. The optimal management of MCC and the choice of treatment modality vary significantly across the world and even between institutions within Australia. Historically, the treatment for MCC has been resection followed by radiotherapy (RT), though definitive RT is an alternative treatment used commonly in Australia. The arrival of immune checkpoint inhibitors and the mounting evidence that MCC is a highly immunogenic disease is transforming the treatment landscape for MCC. Australia is playing a key role in the further development of treatment options for MCC with two upcoming Australian/New Zealand investigator-initiated clinical trials that will explore the interplay of RT and immunotherapy in the treatment of early and late stage MCC.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleThe changing paradigm of managing Merkel cell carcinoma in Australia: An expert commentary
dc.typeJournal Article
dc.identifier.doi10.1111/ajco.13407
melbourne.affiliation.departmentClinical Pathology
melbourne.affiliation.departmentSir Peter MacCallum Department of Oncology
melbourne.source.titleAsia Pacific Journal of Clinical Oncology
melbourne.source.volume16
melbourne.source.issue6
melbourne.source.pages312-319
dc.rights.licenseCC BY-NC-ND
melbourne.elementsid1460778
melbourne.contributor.authorKok, David
melbourne.contributor.authorTothill, Richard
melbourne.contributor.authorSandhu, Shahneen
melbourne.contributor.authorChua, Margaret
dc.identifier.eissn1743-7563
melbourne.accessrightsOpen Access


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