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dc.contributor.authorButcher, R
dc.contributor.authorTagabasoe, J
dc.contributor.authorManemaka, J
dc.contributor.authorBong, A
dc.contributor.authorGarae, M
dc.contributor.authorDaniel, L
dc.contributor.authorRoberts, C
dc.contributor.authorHandley, BL
dc.contributor.authorHu, VH
dc.contributor.authorHarding-Esch, EM
dc.contributor.authorBakhtiari, A
dc.contributor.authorWillis, R
dc.contributor.authorMüller, A
dc.contributor.authorKaldor, J
dc.contributor.authorLe Mesurier, R
dc.contributor.authorMabey, D
dc.contributor.authorCama, A
dc.contributor.authorSokana, O
dc.contributor.authorTaleo, F
dc.contributor.authorTaylor, HR
dc.contributor.authorSolomon, AW
dc.date.accessioned2020-11-27T00:36:58Z
dc.date.available2020-11-27T00:36:58Z
dc.date.issued2020-08-10
dc.identifierpii: 5890405
dc.identifier.citationButcher, R., Tagabasoe, J., Manemaka, J., Bong, A., Garae, M., Daniel, L., Roberts, C., Handley, B. L., Hu, V. H., Harding-Esch, E. M., Bakhtiari, A., Willis, R., Müller, A., Kaldor, J., Le Mesurier, R., Mabey, D., Cama, A., Sokana, O., Taleo, F. ,... Solomon, A. W. (2020). Conjunctival scarring, corneal pannus and Herbert's pits in adolescent children in trachoma-endemic populations of the Solomon Islands and Vanuatu.. Clin Infect Dis, pp.ciaa1151--. https://doi.org/10.1093/cid/ciaa1151.
dc.identifier.issn1058-4838
dc.identifier.urihttp://hdl.handle.net/11343/252525
dc.description.abstractBACKGROUND: In the Solomon Islands and Vanuatu, the sign trachomatous inflammation-follicular (TF) is common, but ocular infection with Chlamydia trachomatis is not. It is therefore debatable whether azithromycin mass drug administration (MDA), the recommended antibiotic treatment strategy for trachoma's elimination as a public health problem, is necessary in this setting. We set out to estimate what proportion of adolescents were at risk of progression of trachomatous scarring. METHODS: A cross-sectional survey was undertaken of all children aged 10-14 years resident in communities identified as high-TF clusters during previous population-based mapping. Graders examined children for clinical evidence of trachomatous scarring, pannus and Herbert's pits (HPs) or limbal follilcles in both eyes. A dried blood spot was collected from each child and tested for antibodies to C. trachomatis. RESULTS: A total of 492 children in 24 villages of the Solomon Islands and Vanuatu were examined. 35/492 (7%) of children had limbal signs (pannus and/or HPs) plus any conjunctival scarring. 9/492 (2%) had limbal signs and moderate or severe conjunctival scarring. 22% of children were anti-Pgp3 seropositve. CONCLUSIONS: Few adolescents here are at risk of future complications from trachoma, supporting the conclusion that further antibiotic MDA is not currently required for trachoma elimination purposes in these settings.
dc.languageeng
dc.publisherOxford University Press (OUP)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleConjunctival scarring, corneal pannus and Herbert's pits in adolescent children in trachoma-endemic populations of the Solomon Islands and Vanuatu.
dc.typeJournal Article
dc.identifier.doi10.1093/cid/ciaa1151
melbourne.affiliation.departmentMelbourne School of Population and Global Health
melbourne.affiliation.departmentOphthalmology (Eye & Ear Hospital)
melbourne.source.titleClinical Infectious Diseases
melbourne.source.pagesciaa1151--
dc.rights.licensecc-by-nc-nd
melbourne.elementsid1461179
melbourne.contributor.authorTaylor, Hugh
melbourne.contributor.authorLe Mesurier, Richard
dc.identifier.eissn1537-6591
melbourne.accessrightsOpen Access


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