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    Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans.

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    Author
    Ling, L; Ren, X; Cao, X; Hassan, ABM; Mah, S; Sathiyanathan, P; Smith, RAA; Tan, CLL; Eio, M; Samsonraj, RM; ...
    Date
    2020-01-14
    Source Title
    Stem Cell Reports
    Publisher
    Elsevier BV
    University of Melbourne Author/s
    Mah, Sophia Ying Yii
    Affiliation
    Medicine Dentistry & Health Sciences
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Ling, L., Ren, X., Cao, X., Hassan, A. B. M., Mah, S., Sathiyanathan, P., Smith, R. A. A., Tan, C. L. L., Eio, M., Samsonraj, R. M., van Wijnen, A. J., Raghunath, M., Nurcombe, V., Hui, J. H. & Cool, S. M. (2020). Enhancing the Efficacy of Stem Cell Therapy with Glycosaminoglycans.. Stem Cell Reports, 14 (1), pp.105-121. https://doi.org/10.1016/j.stemcr.2019.12.003.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252532
    DOI
    10.1016/j.stemcr.2019.12.003
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962655
    Abstract
    Human mesenchymal stem cell (hMSC) therapy offers significant potential for osteochondral regeneration. Such applications require their ex vivo expansion in media frequently supplemented with fibroblast growth factor 2 (FGF2). Particular heparan sulfate (HS) fractions stabilize FGF2-FGF receptor complexes. We show that an FGF2-binding HS variant (HS8) accelerates the expansion of freshly isolated bone marrow hMSCs without compromising their naivety. Importantly, the repair of osteochondral defects in both rats and pigs is improved after treatment with HS8-supplemented hMSCs (MSCHS8), when assessed histologically, biomechanically, or by MRI. Thus, supplementing hMSC culture media with an HS variant that targets endogenously produced FGF2 allows the elimination of exogenous growth factors that may adversely affect their therapeutic potency.

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