Associations of Height With the Risks of Colorectal and Endometrial Cancer in Persons With Lynch Syndrome
AuthorBrouwer, JGM; Newcomb, PA; Bisseling, TM; Figueiredo, JC; Hopper, JL; Jenkins, MA; Koornstra, JJ; Lindor, NM; Vasen, HFA; Win, AK; ...
Source TitleAmerican Journal of Epidemiology
PublisherOXFORD UNIV PRESS INC
AffiliationMelbourne School of Population and Global Health
Document TypeJournal Article
CitationsBrouwer, J. G. M., Newcomb, P. A., Bisseling, T. M., Figueiredo, J. C., Hopper, J. L., Jenkins, M. A., Koornstra, J. J., Lindor, N. M., Vasen, H. F. A., Win, A. K., Kampman, E. & van Duijnhoven, F. J. B. (2021). Associations of Height With the Risks of Colorectal and Endometrial Cancer in Persons With Lynch Syndrome. AMERICAN JOURNAL OF EPIDEMIOLOGY, 190 (2), pp.230-238. https://doi.org/10.1093/aje/kwaa175.
Access StatusOpen Access
NHMRC Grant codeNHMRC/1141746
Persons with Lynch syndrome (LS - carrying a pathogenic mutation in a DNA mismatch repair gene) have an increased colorectal cancer (CRC) and endometrial cancer (EC) risk. A high reported variability in cancer risk suggests the existence of factors that modify cancer risk for LS. We aimed to investigate the association between height and CRC and EC for persons with LS using two large studies. Information of 1,213 men and 1,636 women with LS from the Colon Cancer Family Registry (1998-2007) and the GEOLynch cohort study (2006-2017) was harmonized. We used weighted Cox proportional hazard regression models with age on the time-axis to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for each 5 cm increment in self-reported height. CRC was diagnosed in 947 persons during 65,369 person-years of observation and 171 women were diagnosed with EC during 39,227 person-years of observation. Height was not associated with CRC for men (HR 1.00 per 5 cm, 95%CI: 0.91, 1.11) or women (HR 1.01 per 5 cm, 95%CI: 0.92, 1.11). Nor was height associated with EC (HR 1.08 per 5 cm, 95%CI: 0.94, 1.24). Hence, we observed no evidence for an association of height with either CRC or EC for persons with LS.
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