Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications

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    Author
    Taheri, Y; Suleria, HAR; Martins, N; Sytar, O; Beyatli, A; Yeskaliyeva, B; Seitimova, G; Salehi, B; Semwal, P; Painuli, S; ...
    Date
    2020-08-01
    Source Title
    BMC COMPLEMENTARY MEDICINE AND THERAPIES
    Publisher
    BMC
    University of Melbourne Author/s
    Suleria, Hafiz Ansar Rasul
    Affiliation
    Agriculture and Food Systems
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    Document Type
    Journal Article
    Citations
    Taheri, Y., Suleria, H. A. R., Martins, N., Sytar, O., Beyatli, A., Yeskaliyeva, B., Seitimova, G., Salehi, B., Semwal, P., Painuli, S., Kumar, A., Azzini, E., Martorell, M., Setzer, W. N., Maroyi, A. & Sharifi-Rad, J. (2020). Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications. BMC COMPLEMENTARY MEDICINE AND THERAPIES, 20 (1), https://doi.org/10.1186/s12906-020-03033-z.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252542
    DOI
    10.1186/s12906-020-03033-z
    Abstract
    Several flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricetin has revealed other biological activities, among them as antidiabetic, anticancer, immunomodulatory, cardiovascular, analgesic and antihypertensive. However, few clinical trials have been performed using myricetin as nutraceutical. Thus, this review provides new insights on myricetin preclinical pharmacological activities, and role in selected clinical trials.

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