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dc.contributor.authorRabin, RA
dc.contributor.authorMackey, S
dc.contributor.authorParvaz, MA
dc.contributor.authorCousijn, J
dc.contributor.authorLi, C-S
dc.contributor.authorPearlson, G
dc.contributor.authorSchmaal, L
dc.contributor.authorSinha, R
dc.contributor.authorStein, E
dc.contributor.authorVeltman, D
dc.contributor.authorThompson, PM
dc.contributor.authorConrod, P
dc.contributor.authorGaravan, H
dc.contributor.authorAlia-Klein, N
dc.contributor.authorGoldstein, RZ
dc.date.accessioned2020-11-27T00:40:00Z
dc.date.available2020-11-27T00:40:00Z
dc.date.issued2020-08-28
dc.identifier.citationRabin, R. A., Mackey, S., Parvaz, M. A., Cousijn, J., Li, C. -S., Pearlson, G., Schmaal, L., Sinha, R., Stein, E., Veltman, D., Thompson, P. M., Conrod, P., Garavan, H., Alia-Klein, N. & Goldstein, R. Z. (2020). Common andgender-specificassociations with cocaine use on gray matter volume: Data from theENIGMAaddiction working group. HUMAN BRAIN MAPPING, https://doi.org/10.1002/hbm.25141.
dc.identifier.issn1065-9471
dc.identifier.urihttp://hdl.handle.net/11343/252545
dc.description.abstractGray matter volume (GMV) in frontal cortical and limbic regions is susceptible to cocaine-associated reductions in cocaine-dependent individuals (CD) and is negatively associated with duration of cocaine use. Gender differences in CD individuals have been reported clinically and in the context of neural responses to cue-induced craving and stress reactivity. The variability of GMV in select brain areas between men and women (e.g., limbic regions) underscores the importance of exploring interaction effects between gender and cocaine dependence on brain structure. Therefore, voxel-based morphometry data derived from the ENIGMA Addiction Consortium were used to investigate potential gender differences in GMV in CD individuals compared to matched controls (CTL). T1-weighted MRI scans and clinical data were pooled from seven sites yielding 420 gender- and age-matched participants: CD men (CDM, n = 140); CD women (CDW, n = 70); control men (CTLM, n = 140); and control women (CTLW, n = 70). Differences in GMV were assessed using a 2 × 2 ANCOVA, and voxelwise whole-brain linear regressions were conducted to explore relationships between GMV and duration of cocaine use. All analyses were corrected for age, total intracranial volume, and site. Diagnostic differences were predominantly found in frontal regions (CD < CTL). Interestingly, gender × diagnosis interactions in the left anterior insula and left lingual gyrus were also documented, driven by differences in women (CDW < CTLW). Further, lower right hippocampal GMV was associated with greater cocaine duration in CDM. Given the importance of the anterior insula to interoception and the hippocampus to learning contextual associations, results may point to gender-specific mechanisms in cocaine addiction.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
dc.titleCommon andgender-specificassociations with cocaine use on gray matter volume: Data from theENIGMAaddiction working group
dc.typeJournal Article
dc.identifier.doi10.1002/hbm.25141
melbourne.affiliation.departmentCentre for Youth Mental Health
melbourne.source.titleHuman Brain Mapping
melbourne.identifier.nhmrc1140764
dc.rights.licensecc-by-nc-nd
melbourne.elementsid1463414
melbourne.contributor.authorSchmaal, Lianne
dc.identifier.eissn1097-0193
melbourne.identifier.fundernameidNHMRC, 1140764
melbourne.identifier.fundernameidNATIONAL INSTITUTE OF HEALTH, R01MH117601 / 108606875
melbourne.accessrightsOpen Access


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