Show simple item record

dc.contributor.authorDemetri, GD
dc.contributor.authorAntonescu, CR
dc.contributor.authorBjerkehagen, B
dc.contributor.authorBovee, JVMG
dc.contributor.authorBoye, K
dc.contributor.authorChacon, M
dc.contributor.authorDei Tos, AP
dc.contributor.authorDesai, J
dc.contributor.authorFletcher, JA
dc.contributor.authorGelderblom, H
dc.contributor.authorGeorge, S
dc.contributor.authorGronchi, A
dc.contributor.authorHaas, RL
dc.contributor.authorHindi, N
dc.contributor.authorHohenberger, P
dc.contributor.authorJoensuu, H
dc.contributor.authorJones, RL
dc.contributor.authorJudson, I
dc.contributor.authorKang, Y-K
dc.contributor.authorKawai, A
dc.contributor.authorLazar, AJ
dc.contributor.authorLe Cesne, A
dc.contributor.authorMaestro, R
dc.contributor.authorMaki, RG
dc.contributor.authorMartin, J
dc.contributor.authorPatel, S
dc.contributor.authorPenault-Llorca, F
dc.contributor.authorRaut, CP
dc.contributor.authorRutkowski, P
dc.contributor.authorSafwat, A
dc.contributor.authorSbaraglia, M
dc.contributor.authorSchaefer, I-M
dc.contributor.authorShen, L
dc.contributor.authorSerrano, C
dc.contributor.authorSchoffski, P
dc.contributor.authorStacchiotti, S
dc.contributor.authorSundby Hall, K
dc.contributor.authorTap, WD
dc.contributor.authorThomas, DM
dc.contributor.authorTrent, J
dc.contributor.authorValverde, C
dc.contributor.authorvan der Graaf, WTA
dc.contributor.authorvon Mehren, M
dc.contributor.authorWagner, A
dc.contributor.authorWardelmann, E
dc.contributor.authorNaito, Y
dc.contributor.authorZalcberg, J
dc.contributor.authorBlay, J-Y
dc.date.accessioned2020-11-27T00:42:22Z
dc.date.available2020-11-27T00:42:22Z
dc.date.issued2020-11-01
dc.identifierpii: S0923-7534(20)42297-5
dc.identifier.citationDemetri, G. D., Antonescu, C. R., Bjerkehagen, B., Bovee, J. V. M. G., Boye, K., Chacon, M., Dei Tos, A. P., Desai, J., Fletcher, J. A., Gelderblom, H., George, S., Gronchi, A., Haas, R. L., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R. L., Judson, I., Kang, Y. -K. ,... Blay, J. -Y. (2020). Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network. ANNALS OF ONCOLOGY, 31 (11), pp.1506-1517. https://doi.org/10.1016/j.annonc.2020.08.2232.
dc.identifier.issn0923-7534
dc.identifier.urihttp://hdl.handle.net/11343/252561
dc.description.abstractSarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a subset of patients with sarcoma in the form of tropomyosin receptor kinase (TRK) inhibitors. NTRK gene rearrangements and fusion transcripts can be detected with different molecular pathology techniques, while TRK protein expression can be demonstrated with immunohistochemistry. The rarity and diagnostic complexity of NTRK gene fusions raise a number of questions and challenges for clinicians. To address these challenges, the World Sarcoma Network convened two meetings of expert adult oncologists and pathologists and subsequently developed this article to provide practical guidance on the management of patients with sarcoma harboring NTRK gene fusions. We propose a diagnostic strategy that considers disease stage and histologic and molecular subtypes to facilitate routine testing for TRK expression and subsequent testing for NTRK gene fusions.
dc.languageEnglish
dc.publisherELSEVIER
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDiagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
dc.typeJournal Article
dc.identifier.doi10.1016/j.annonc.2020.08.2232
melbourne.affiliation.departmentMedicine and Radiology
melbourne.source.titleAnnals of Oncology
melbourne.source.volume31
melbourne.source.issue11
melbourne.source.pages1506-1517
dc.rights.licenseCC BY
melbourne.elementsid1464606
melbourne.contributor.authorDesai, Jayesh
melbourne.contributor.authorZalcberg, John
dc.identifier.eissn1569-8041
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record