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    Biased MAIT TCR Usage Poised for Limited Antigen Diversity?

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    Author
    Souter, MNT; Eckle, SBG
    Date
    2020-08-18
    Source Title
    Frontiers in Immunology
    Publisher
    FRONTIERS MEDIA SA
    University of Melbourne Author/s
    Eckle, Sidonia; Souter, Michael
    Affiliation
    Microbiology and Immunology
    Metadata
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    Document Type
    Journal Article
    Citations
    Souter, M. N. T. & Eckle, S. B. G. (2020). Biased MAIT TCR Usage Poised for Limited Antigen Diversity?. FRONTIERS IN IMMUNOLOGY, 11, https://doi.org/10.3389/fimmu.2020.01845.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252562
    DOI
    10.3389/fimmu.2020.01845
    Abstract
    Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells that recognize the evolutionarily conserved major histocompatibility complex (MHC) class I-like antigen-presenting molecule known as MHC class I related protein 1 (MR1). Since their rise from obscurity in the early 1990s, the study of MAIT cells has grown substantially, accelerating our fundamental understanding of these cells and their possible roles in immunity. In the context of recent advances, we review here the relationship between MR1, antigen, and TCR usage among MAIT and other MR1-reactive T cells and provide a speculative discussion.

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