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dc.contributor.authorGonen, OM
dc.contributor.authorMoffat, BA
dc.contributor.authorKwan, P
dc.contributor.authorO'Brien, TJ
dc.contributor.authorDesmond, PM
dc.contributor.authorLui, E
dc.date.accessioned2020-11-27T00:43:03Z
dc.date.available2020-11-27T00:43:03Z
dc.date.issued2020-09-15
dc.identifier.citationGonen, O. M., Moffat, B. A., Kwan, P., O'Brien, T. J., Desmond, P. M. & Lui, E. (2020). Reproducibility of Glutamate, Glutathione, and GABA Measurementsin vivoby Single-Voxel STEAM Magnetic Resonance Spectroscopy at 7-Tesla in Healthy Individuals. FRONTIERS IN NEUROSCIENCE, 14, https://doi.org/10.3389/fnins.2020.566643.
dc.identifier.issn1662-4548
dc.identifier.urihttp://hdl.handle.net/11343/252566
dc.description.abstractBackground and Purpose: Derangements in brain glutamate, glutathione, and γ-amino butyric acid (GABA) are implicated in a range of neurological disorders. Reliable methods to measure these compounds non-invasively in vivo are needed. We evaluated the reproducibility of their measurements in brain regions involved in the default mode network using quantitative MRS at 7-Tesla in healthy individuals. Methods: Ten right-handed healthy volunteers underwent 7-Tesla MRI scans on 2 separate days, not more than 2 weeks apart. On each day two scanning sessions took place, with a re-positioning break in between. High-resolution isotropic anatomical scans were acquired prior to each scan, followed by single-voxel 1H-MRS using the STEAM pulse sequence on an 8 mL midline cubic voxel, positioned over the posterior cingulate and precuneus regions. Concentrations were corrected for partial-volume effects. Results: Maximal Cramér-Rao lower bounds for glutamate, glutathione, and GABA were 2.0, 8.0, and 14.0%, respectively. Mean coefficients of variation within sessions were 5.9 ± 4.8%, 9.3 ± 7.6%, and 11.5 ± 8.8%, and between sessions were 4.6 ± 4.5%, 8.3 ± 5.7%, and 9.2 ± 8.7%, respectively. The mean (±SD) Dice's coefficient for voxel overlap was 90 ± 4% within sessions and 86 ± 7% between sessions. Conclusion: Glutamate, glutathione, and GABA can be reliably quantified using STEAM MRS at 7-Tesla from the posterior cingulate and precuneus cortices of healthy human subjects. STEAM MRS at 7-Tesla may be used to study the metabolic behavior of this important resting-state hub in various disease states.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleReproducibility of Glutamate, Glutathione, and GABA Measurementsin vivoby Single-Voxel STEAM Magnetic Resonance Spectroscopy at 7-Tesla in Healthy Individuals
dc.typeJournal Article
dc.identifier.doi10.3389/fnins.2020.566643
melbourne.affiliation.departmentMedicine and Radiology
melbourne.affiliation.department
melbourne.source.titleFrontiers in Neuroscience
melbourne.source.volume14
dc.rights.licenseCC BY
melbourne.elementsid1464958
melbourne.contributor.authorLui, Elaine
melbourne.contributor.authorGonen, Ofer Michael
melbourne.contributor.authorMoffat, Bradford
melbourne.contributor.authorKwan, Patrick
melbourne.contributor.authorDesmond, Patricia
dc.identifier.eissn1662-453X
melbourne.accessrightsOpen Access


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