Resistance to natural and synthetic gene drive systems

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    Author
    Price, TAR; Windbichler, N; Unckless, RL; Sutter, A; Runge, J-N; Ross, PA; Pomiankowski, A; Nuckolls, NL; Montchamp-Moreau, C; Mideo, N; ...
    Date
    2020-10
    Source Title
    Journal of Evolutionary Biology
    Publisher
    WILEY
    University of Melbourne Author/s
    Holman, Luke; Stott-Ross, Perran
    Affiliation
    School of BioSciences
    Metadata
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    Document Type
    Journal Article
    Citations
    Price, T. A. R., Windbichler, N., Unckless, R. L., Sutter, A., Runge, J. -N., Ross, P. A., Pomiankowski, A., Nuckolls, N. L., Montchamp-Moreau, C., Mideo, N., Martin, O. Y., Manser, A., Legros, M., Larracuente, A. M., Holman, L., Godwin, J., Gemmell, N., Courret, C., Buchman, A. ,... Lindholm, A. K. (2020). Resistance to natural and synthetic gene drive systems. JOURNAL OF EVOLUTIONARY BIOLOGY, 33 (10), pp.1345-1360. https://doi.org/10.1111/jeb.13693.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252576
    DOI
    10.1111/jeb.13693
    Abstract
    Scientists are rapidly developing synthetic gene drive elements intended for release into natural populations. These are intended to control or eradicate disease vectors and pests, or to spread useful traits through wild populations for disease control or conservation purposes. However, a crucial problem for gene drives is the evolution of resistance against them, preventing their spread. Understanding the mechanisms by which populations might evolve resistance is essential for engineering effective gene drive systems. This review summarizes our current knowledge of drive resistance in both natural and synthetic gene drives. We explore how insights from naturally occurring and synthetic drive systems can be integrated to improve the design of gene drives, better predict the outcome of releases and understand genomic conflict in general.

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