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    Dysregulated Lipid Metabolism Precedes Onset of Psychosis

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    Author
    Dickens, AM; Sen, P; Kempton, MJ; Barrantes-Vidal, N; Iyegbe, C; Nordentoft, M; Pollak, T; Riecher-Rossler, A; Ruhrmann, S; Sachs, G; ...
    Date
    2021-02-01
    Source Title
    Biological Psychiatry
    Publisher
    ELSEVIER SCIENCE INC
    University of Melbourne Author/s
    Amminger, Guenter
    Affiliation
    Centre for Youth Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Dickens, A. M., Sen, P., Kempton, M. J., Barrantes-Vidal, N., Iyegbe, C., Nordentoft, M., Pollak, T., Riecher-Rossler, A., Ruhrmann, S., Sachs, G., Bressan, R., Krebs, M. -O., Amminger, G. P., de Haan, L., van der Gaag, M., Valmaggia, L., Hyotylainen, T., Oresic, M. & McGuire, P. (2021). Dysregulated Lipid Metabolism Precedes Onset of Psychosis. BIOLOGICAL PSYCHIATRY, 89 (3), pp.288-297. https://doi.org/10.1016/j.biopsych.2020.07.012.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252578
    DOI
    10.1016/j.biopsych.2020.07.012
    Abstract
    BACKGROUND: A key clinical challenge in the management of individuals at clinical high risk for psychosis (CHR) is that it is difficult to predict their future clinical outcomes. Here, we investigated if the levels of circulating molecular lipids are related to adverse clinical outcomes in this group. METHODS: Serum lipidomic analysis was performed in 263 CHR individuals and 51 healthy control subjects, who were then clinically monitored for up to 5 years. Machine learning was used to identify lipid profiles that discriminated between CHR and control subjects, and between subgroups of CHR subjects with distinct clinical outcomes. RESULTS: At baseline, compared with control subjects, CHR subjects (independent of outcome) had higher levels of triacylglycerols with a low acyl carbon number and a double bond count, as well as higher levels of lipids in general. CHR subjects who subsequently developed psychosis (n = 50) were distinguished from those that did not (n = 213) on the basis of lipid profile at baseline using a model with an area under the receiver operating curve of 0.81 (95% confidence interval = 0.69-0.93). CHR subjects who became psychotic had lower levels of ether phospholipids than CHR individuals who did not (p < .01). CONCLUSIONS: Collectively, these data suggest that lipidomic abnormalities predate the onset of psychosis and that blood lipidomic measures may be useful in predicting which CHR individuals are most likely to develop psychosis.

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