Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release
AuthorHuang, B; Yang, Q; Hoffmann, AA; Ritchie, SA; van den Hurk, AF; Warrilow, D
University of Melbourne Author/sHoffmann, Ary
AffiliationSchool of BioSciences
Document TypeJournal Article
CitationsHuang, B., Yang, Q., Hoffmann, A. A., Ritchie, S. A., van den Hurk, A. F. & Warrilow, D. (2020). Wolbachia Genome Stability and mtDNA Variants in Aedes aegypti Field Populations Eight Years after Release. ISCIENCE, 23 (10), https://doi.org/10.1016/j.isci.2020.101572.
Access StatusOpen Access
Open Access at PMChttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527712
A dengue suppression strategy based on release of Aedes aegypti mosquitoes infected with the bacterium Wolbachia pipientis is being trialed in many countries. Wolbachia inhibits replication and transmission of dengue viruses. Questions remain regarding the long-term stability of virus-suppressive effects. We sequenced the Wolbachia genome and analyzed Ae. aegypti mitochondrial DNA markers isolated from mosquitoes sampled 2-8 years after releases in the greater Cairns region, Australia. Few changes were detected when Wolbachia genomes of field mosquitoes were compared with Wolbachia genomes of mosquitoes obtained soon after initial releases. Mitochondrial variants associated with the initial Wolbachia release stock are now the only variants found in release sites, highlighting maternal leakage as a possible explanation for rare Wolbachia-negative mosquitoes and not migration from non-release areas. There is no evidence of changes in the Wolbachia genome that indicate selection against its viral-suppressive effects or other phenotypes attributable to infection with the bacterium.
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References