University Library
  • Login
A gateway to Melbourne's research publications
Minerva Access is the University's Institutional Repository. It aims to collect, preserve, and showcase the intellectual output of staff and students of the University of Melbourne for a global audience.
View Item 
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Psychiatry
  • Psychiatry - Research Publications
  • View Item
  • Minerva Access
  • Medicine, Dentistry & Health Sciences
  • Melbourne Medical School
  • Psychiatry
  • Psychiatry - Research Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

    Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19

    Thumbnail
    Download
    Published version (168.7Kb)

    Citations
    Altmetric
    Author
    Pantelis, C; Jayaram, M; Hannan, AJ; Wesselingh, R; Nithianantharajah, J; Wannan, CMJ; Syeda, WT; Choy, KHC; Zantomio, D; Christopoulos, A; ...
    Date
    2020-10-01
    Source Title
    Australian and New Zealand Journal of Psychiatry
    Publisher
    SAGE PUBLICATIONS LTD
    University of Melbourne Author/s
    Pantelis, Christos; Jayaram, Mahesh; Hannan, Anthony; Nithianantharajah, Jess; Wannan, Cassandra; Wannan, Cassandra Marie Joanne
    Affiliation
    Psychiatry
    Florey Department of Neuroscience and Mental Health
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Pantelis, C., Jayaram, M., Hannan, A. J., Wesselingh, R., Nithianantharajah, J., Wannan, C. M. J., Syeda, W. T., Choy, K. H. C., Zantomio, D., Christopoulos, A., Velakoulis, D. & O'Brien, T. J. (2020). Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19. AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, https://doi.org/10.1177/0004867420961472.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252596
    DOI
    10.1177/0004867420961472
    Abstract
    Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highlight the impact of SARS-CoV-2 (the coronavirus causing COVID-19) on the central nervous system as there is an urgent need to understand the longitudinal impacts of COVID-19 on brain function, behaviour and cognition. Furthermore, we address the possibility of intergenerational impacts of COVID-19 on the brain, potentially via both maternal and paternal routes. Evidence from preclinical models of earlier coronaviruses has shown direct viral infiltration across the blood-brain barrier and indirect secondary effects due to other organ pathology and inflammation. In the most severely ill patients with pneumonia requiring intensive care, there appears to be additional severe inflammatory response and associated thrombophilia with widespread organ damage, including the brain. Maternal viral (and other) infections during pregnancy can affect the offspring, with greater incidence of neurodevelopmental disorders, such as autism, schizophrenia and epilepsy. Available reports suggest possible vertical transmission of SARS-CoV-2, although longitudinal cohort studies of such offspring are needed. The impact of paternal infection on the offspring and intergenerational effects should also be considered. Research targeted at mechanistic insights into all aspects of pathogenesis, including neurological, neuropsychiatric and haematological systems alongside pulmonary pathology, will be critical in informing future therapeutic approaches. With these future challenges in mind, we highlight the importance of national and international collaborative efforts to gather the required clinical and preclinical data to effectively address the possible long-term sequelae of this global pandemic, particularly with respect to the brain and mental health.

    Export Reference in RIS Format     

    Endnote

    • Click on "Export Reference in RIS Format" and choose "open with... Endnote".

    Refworks

    • Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References


    Collections
    • Minerva Elements Records [53102]
    • Florey Department of Neuroscience and Mental Health - Research Publications [1300]
    • Psychiatry - Research Publications [1380]
    Minerva AccessDepositing Your Work (for University of Melbourne Staff and Students)NewsFAQs

    BrowseCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects
    My AccountLoginRegister
    StatisticsMost Popular ItemsStatistics by CountryMost Popular Authors