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dc.contributor.authorGurholt, TP
dc.contributor.authorLonning, V
dc.contributor.authorNerland, S
dc.contributor.authorJorgensen, KN
dc.contributor.authorHaukvik, UK
dc.contributor.authorAlloza, C
dc.contributor.authorArango, C
dc.contributor.authorBarth, C
dc.contributor.authorBearden, CE
dc.contributor.authorBerk, M
dc.contributor.authorBohman, H
dc.contributor.authorDandash, O
dc.contributor.authorDiaz-Caneja, CM
dc.contributor.authorEdbom, CT
dc.contributor.authorvan Erp, TGM
dc.contributor.authorFett, A-KJ
dc.contributor.authorFrangou, S
dc.contributor.authorGoldstein, BI
dc.contributor.authorGrigorian, A
dc.contributor.authorJahanshad, N
dc.contributor.authorJames, AC
dc.contributor.authorJanssen, J
dc.contributor.authorJohannessen, C
dc.contributor.authorKarlsgodt, KH
dc.contributor.authorKempton, MJ
dc.contributor.authorKochunov, P
dc.contributor.authorKrabbendam, L
dc.contributor.authorKyriakopoulos, M
dc.contributor.authorLundberg, M
dc.contributor.authorMacIntosh, BJ
dc.contributor.authorRund, BR
dc.contributor.authorSmelror, RE
dc.contributor.authorSultan, A
dc.contributor.authorTamnes, CK
dc.contributor.authorThomopoulos, SI
dc.contributor.authorVajdi, A
dc.contributor.authorWedervang-Resell, K
dc.contributor.authorMyhre, AM
dc.contributor.authorAndreassen, OA
dc.contributor.authorThompson, PM
dc.contributor.authorAgartz, I
dc.date.accessioned2020-11-27T00:49:21Z
dc.date.available2020-11-27T00:49:21Z
dc.date.issued2020-10-05
dc.identifier.citationGurholt, T. P., Lonning, V., Nerland, S., Jorgensen, K. N., Haukvik, U. K., Alloza, C., Arango, C., Barth, C., Bearden, C. E., Berk, M., Bohman, H., Dandash, O., Diaz-Caneja, C. M., Edbom, C. T., van Erp, T. G. M., Fett, A. -K. J., Frangou, S., Goldstein, B. I., Grigorian, A. ,... Agartz, I. (2020). Intracranial and subcortical volumes in adolescents withearly-onsetpsychosis: A multisitemega-analysisfrom theENIGMAconsortium. HUMAN BRAIN MAPPING, https://doi.org/10.1002/hbm.25212.
dc.identifier.issn1065-9471
dc.identifier.urihttp://hdl.handle.net/11343/252605
dc.description.abstractEarly-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = -0.39) and hippocampal (d = -0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = -0.34) and affective psychosis (d = -0.42), and early-onset schizophrenia showed lower hippocampal (d = -0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = -0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleIntracranial and subcortical volumes in adolescents withearly-onsetpsychosis: A multisitemega-analysisfrom theENIGMAconsortium
dc.typeJournal Article
dc.identifier.doi10.1002/hbm.25212
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleHuman Brain Mapping
dc.rights.licensecc-by
melbourne.elementsid1467964
melbourne.contributor.authorBerk, Michael
melbourne.contributor.authorDandash, Orwa
dc.identifier.eissn1097-0193
melbourne.identifier.fundernameidNATIONAL INSTITUTE OF HEALTH, R01MH117601 / 108606875
melbourne.accessrightsOpen Access


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