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dc.contributor.authorAl-Sarraj, S
dc.contributor.authorTroakes, C
dc.contributor.authorHanley, B
dc.contributor.authorOsborn, M
dc.contributor.authorRichardson, MP
dc.contributor.authorHotopf, M
dc.contributor.authorBullmore, E
dc.contributor.authorEverall, IP
dc.date.accessioned2020-11-27T00:52:12Z
dc.date.available2020-11-27T00:52:12Z
dc.date.issued2020-10-20
dc.identifier.citationAl-Sarraj, S., Troakes, C., Hanley, B., Osborn, M., Richardson, M. P., Hotopf, M., Bullmore, E. & Everall, I. P. (2020). Invited Review: The spectrum of neuropathology in COVID-19. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 47 (1), pp.3-16. https://doi.org/10.1111/nan.12667.
dc.identifier.issn0305-1846
dc.identifier.urihttp://hdl.handle.net/11343/252622
dc.description.abstractThere is increasing evidence that patients with Coronavirus disease 19 (COVID-19) present with neurological and psychiatric symptoms. Anosmia, hypogeusia, headache, nausea and altered consciousness are commonly described, although there are emerging clinical reports of more serious and specific conditions such as acute cerebrovascular accident, encephalitis and demyelinating disease. Whether these presentations are directly due to viral invasion of the central nervous system (CNS) or caused by indirect mechanisms has yet to be established. Neuropathological examination of brain tissue at autopsy will be essential to establish the neuro-invasive potential of the SARS-CoV-2 virus but, to date, there have been few detailed studies. The pathological changes in the brain probably represent a combination of direct cytopathic effects mediated by SARS-CoV-2 replication or indirect effects due to respiratory failure, injurious cytokine reaction, reduced immune response and cerebrovascular accidents induced by viral infection. Further large-scale molecular and cellular investigations are warranted to clarify the neuropathological correlates of the neurological and psychiatric features seen clinically in COVID-19. In this review, we summarize the current reports of neuropathological examination in COVID-19 patients, in addition to our own experience, and discuss their contribution to the understanding of CNS involvement in this disease.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleInvited Review: The spectrum of neuropathology in COVID-19
dc.typeJournal Article
dc.identifier.doi10.1111/nan.12667
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleNeuropathology and Applied Neurobiology
melbourne.source.volume47
melbourne.source.issue1
melbourne.source.pages3-16
dc.rights.licensecc-by
melbourne.elementsid1469010
melbourne.contributor.authorEverall, Ian
dc.identifier.eissn1365-2990
melbourne.accessrightsOpen Access


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