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dc.contributor.authorHaukvik, UK
dc.contributor.authorGurholt, TP
dc.contributor.authorNerland, S
dc.contributor.authorElvsashagen, T
dc.contributor.authorAkudjedu, TN
dc.contributor.authorAlda, M
dc.contributor.authorAlnaes, D
dc.contributor.authorAlonso-Lana, S
dc.contributor.authorBauer, J
dc.contributor.authorBaune, BT
dc.contributor.authorBenedetti, F
dc.contributor.authorBerk, M
dc.contributor.authorBettella, F
dc.contributor.authorBoen, E
dc.contributor.authorBonnin, CM
dc.contributor.authorBrambilla, P
dc.contributor.authorCanales-Rodriguez, EJ
dc.contributor.authorCannon, DM
dc.contributor.authorCaseras, X
dc.contributor.authorDandash, O
dc.contributor.authorDannlowski, U
dc.contributor.authorDelvecchio, G
dc.contributor.authorDiaz-Zuluaga, AM
dc.contributor.authorErp, TGM
dc.contributor.authorFatjo-Vilas, M
dc.contributor.authorFoley, SF
dc.contributor.authorFoerster, K
dc.contributor.authorFullerton, JM
dc.contributor.authorGoikolea, JM
dc.contributor.authorGrotegerd, D
dc.contributor.authorGruber, O
dc.contributor.authorHaarman, BCM
dc.contributor.authorHaatveit, B
dc.contributor.authorHajek, T
dc.contributor.authorHallahan, B
dc.contributor.authorHarris, M
dc.contributor.authorHawkins, EL
dc.contributor.authorHowells, FM
dc.contributor.authorHuelsmann, C
dc.contributor.authorJahanshad, N
dc.contributor.authorJorgensen, KN
dc.contributor.authorKircher, T
dc.contributor.authorKraemer, B
dc.contributor.authorKrug, A
dc.contributor.authorKuplicki, R
dc.contributor.authorLagerberg, T
dc.contributor.authorLancaster, TM
dc.contributor.authorLenroot, RK
dc.contributor.authorLonning, V
dc.contributor.authorLopez-Jaramillo, C
dc.contributor.authorMalt, UF
dc.contributor.authorMcDonald, C
dc.contributor.authorMcIntosh, AM
dc.contributor.authorMcPhilemy, G
dc.contributor.authorMeer, D
dc.contributor.authorMelle, I
dc.contributor.authorMelloni, EMT
dc.contributor.authorMitchell, PB
dc.contributor.authorNabulsi, L
dc.contributor.authorNenadic, I
dc.contributor.authorOertel, V
dc.contributor.authorOldani, L
dc.contributor.authorOpel, N
dc.contributor.authorOtaduy, MCG
dc.contributor.authorOvers, BJ
dc.contributor.authorPineda-Zapata, JA
dc.contributor.authorPomarol-Clotet, E
dc.contributor.authorRadua, J
dc.contributor.authorRauer, L
dc.contributor.authorRedlich, R
dc.contributor.authorRepple, J
dc.contributor.authorRive, MM
dc.contributor.authorRoberts, G
dc.contributor.authorRuhe, HG
dc.contributor.authorSalminen, LE
dc.contributor.authorSalvador, R
dc.contributor.authorSarro, S
dc.contributor.authorSavitz, J
dc.contributor.authorSchene, AH
dc.contributor.authorSim, K
dc.contributor.authorSoeiro-de-Souza, MG
dc.contributor.authorStaeblein, M
dc.contributor.authorStein, DJ
dc.contributor.authorStein, F
dc.contributor.authorTamnes, CK
dc.contributor.authorTemmingh, HS
dc.contributor.authorThomopoulos, S
dc.contributor.authorVeltman, DJ
dc.contributor.authorVieta, E
dc.contributor.authorWaltemate, L
dc.contributor.authorWestlye, LT
dc.contributor.authorWhalley, HC
dc.contributor.authorSaemann, PG
dc.contributor.authorThompson, PM
dc.contributor.authorChing, CRK
dc.contributor.authorAndreassen, OA
dc.contributor.authorAgartz, I
dc.date.accessioned2020-11-27T00:54:41Z
dc.date.available2020-11-27T00:54:41Z
dc.date.issued2020-10-19
dc.identifier.citationHaukvik, U. K., Gurholt, T. P., Nerland, S., Elvsashagen, T., Akudjedu, T. N., Alda, M., Alnaes, D., Alonso-Lana, S., Bauer, J., Baune, B. T., Benedetti, F., Berk, M., Bettella, F., Boen, E., Bonnin, C. M., Brambilla, P., Canales-Rodriguez, E. J., Cannon, D. M., Caseras, X. ,... Agartz, I. (2020). In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics throughMeta-AnalysisBipolar Disorder Working Group. HUMAN BRAIN MAPPING, https://doi.org/10.1002/hbm.25249.
dc.identifier.issn1065-9471
dc.identifier.urihttp://hdl.handle.net/11343/252636
dc.description.abstractThe hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.
dc.languageEnglish
dc.publisherWILEY
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleIn vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics throughMeta-AnalysisBipolar Disorder Working Group
dc.typeJournal Article
dc.identifier.doi10.1002/hbm.25249
melbourne.affiliation.departmentPsychiatry
melbourne.source.titleHuman Brain Mapping
dc.rights.licensecc-by
melbourne.elementsid1469346
melbourne.contributor.authorBerk, Michael
melbourne.contributor.authorBaune, Bernhard
dc.identifier.eissn1097-0193
melbourne.accessrightsOpen Access


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