Show simple item record

dc.contributor.authorWood, TE
dc.contributor.authorAksoy, E
dc.contributor.authorHachani, A
dc.date.accessioned2020-11-27T00:54:49Z
dc.date.available2020-11-27T00:54:49Z
dc.date.issued2020-10-19
dc.identifier.citationWood, T. E., Aksoy, E. & Hachani, A. (2020). From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 10, https://doi.org/10.3389/fcimb.2020.587948.
dc.identifier.issn2235-2988
dc.identifier.urihttp://hdl.handle.net/11343/252637
dc.description.abstractThe health of mammals depends on a complex interplay with their microbial ecosystems. Compartments exposed to external environments such as the mucosal surfaces of the gastrointestinal tract accommodate the gut microbiota, composed by a wide range of bacteria. The gut microbiome confers benefits to the host, including expansion of metabolic potential and the development of an immune system that can robustly protect from external and internal insults. The cooperation between gut microbiome and host is enabled in part by the formation of partitioned niches that harbor diverse bacterial phyla. Bacterial secretion systems are commonly employed to manipulate the composition of these local environments. Here, we explore the roles of the bacterial type VI secretion system (T6SS), present in ~25% of gram-negative bacteria, including many symbionts, in the establishment and perturbation of bacterial commensalism, and symbiosis in host mucosal sites. This versatile apparatus drives bacterial competition, although in some cases can also interfere directly with host cells and facilitate nutrient acquisition. In addition, some bacterial pathogens cause disease when their T6SS leads to dysbiosis and subverts host immune responses in defined animal models. This review explores our knowledge of the T6SS in the context of the "host-microbiota-pathogen" triumvirate and examines contexts in which the importance of this secretion system may be underappreciated.
dc.languageEnglish
dc.publisherFRONTIERS MEDIA SA
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleFrom Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System
dc.typeJournal Article
dc.identifier.doi10.3389/fcimb.2020.587948
melbourne.affiliation.departmentMicrobiology and Immunology
melbourne.source.titleFrontiers in Cellular and Infection Microbiology
melbourne.source.volume10
dc.rights.licenseCC BY
melbourne.elementsid1469459
melbourne.contributor.authorHachani, Abderrahman
dc.identifier.eissn2235-2988
melbourne.accessrightsOpen Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record