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    ThermoMutDB: a thermodynamic database for missense mutations.

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    Author
    Xavier, JS; Nguyen, T-B; Karmarkar, M; Portelli, S; Rezende, PM; Velloso, JPL; Ascher, DB; Pires, DEV
    Date
    2020-10-23
    Source Title
    Nucleic Acids Research
    Publisher
    Oxford University Press
    University of Melbourne Author/s
    Ascher, David; Pires, Douglas; Portelli, Stephanie; Karmakar, Malancha; Nguyen, Thanh-Binh
    Affiliation
    Biochemistry and Molecular Biology

    Computing and Information Systems
    Bio21
    Metadata
    Show full item record
    Document Type
    Journal Article
    Citations
    Xavier, J. S., Nguyen, T. -B., Karmarkar, M., Portelli, S., Rezende, P. M., Velloso, J. P. L., Ascher, D. B. & Pires, D. E. V. (2020). ThermoMutDB: a thermodynamic database for missense mutations.. Nucleic Acids Research, 49 (D1), pp.D475-D479. https://doi.org/10.1093/nar/gkaa925.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252648
    DOI
    10.1093/nar/gkaa925
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778973
    Abstract
    Proteins are intricate, dynamic structures, and small changes in their amino acid sequences can lead to large effects on their folding, stability and dynamics. To facilitate the further development and evaluation of methods to predict these changes, we have developed ThermoMutDB, a manually curated database containing >14,669 experimental data of thermodynamic parameters for wild type and mutant proteins. This represents an increase of 83% in unique mutations over previous databases and includes thermodynamic information on 204 new proteins. During manual curation we have also corrected annotation errors in previously curated entries. Associated with each entry, we have included information on the unfolding Gibbs free energy and melting temperature change, and have associated entries with available experimental structural information. ThermoMutDB supports users to contribute to new data points and programmatic access to the database via a RESTful API. ThermoMutDB is freely available at: http://biosig.unimelb.edu.au/thermomutdb.

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