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dc.contributor.authorXavier, JS
dc.contributor.authorNguyen, T-B
dc.contributor.authorKarmarkar, M
dc.contributor.authorPortelli, S
dc.contributor.authorRezende, PM
dc.contributor.authorVelloso, JPL
dc.contributor.authorAscher, DB
dc.contributor.authorPires, DEV
dc.date.accessioned2020-11-27T00:56:30Z
dc.date.available2020-11-27T00:56:30Z
dc.date.issued2020-10-23
dc.identifierpii: 5937085
dc.identifier.citationXavier, J. S., Nguyen, T. -B., Karmarkar, M., Portelli, S., Rezende, P. M., Velloso, J. P. L., Ascher, D. B. & Pires, D. E. V. (2020). ThermoMutDB: a thermodynamic database for missense mutations.. Nucleic Acids Research, 49 (D1), pp.D475-D479. https://doi.org/10.1093/nar/gkaa925.
dc.identifier.issn0305-1048
dc.identifier.urihttp://hdl.handle.net/11343/252648
dc.description.abstractProteins are intricate, dynamic structures, and small changes in their amino acid sequences can lead to large effects on their folding, stability and dynamics. To facilitate the further development and evaluation of methods to predict these changes, we have developed ThermoMutDB, a manually curated database containing >14,669 experimental data of thermodynamic parameters for wild type and mutant proteins. This represents an increase of 83% in unique mutations over previous databases and includes thermodynamic information on 204 new proteins. During manual curation we have also corrected annotation errors in previously curated entries. Associated with each entry, we have included information on the unfolding Gibbs free energy and melting temperature change, and have associated entries with available experimental structural information. ThermoMutDB supports users to contribute to new data points and programmatic access to the database via a RESTful API. ThermoMutDB is freely available at: http://biosig.unimelb.edu.au/thermomutdb.
dc.languageeng
dc.publisherOxford University Press
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThermoMutDB: a thermodynamic database for missense mutations.
dc.typeJournal Article
dc.identifier.doi10.1093/nar/gkaa925
melbourne.affiliation.departmentBiochemistry and Molecular Biology
melbourne.affiliation.department
melbourne.affiliation.departmentComputing and Information Systems
melbourne.affiliation.departmentBio21
melbourne.source.titleNucleic Acids Research
melbourne.source.volume49
melbourne.source.issueD1
melbourne.source.pagesD475-D479
melbourne.identifier.nhmrc1174405
dc.rights.licenseCC BY
melbourne.elementsid1474259
melbourne.openaccess.pmchttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778973
melbourne.contributor.authorAscher, David
melbourne.contributor.authorPires, Douglas
melbourne.contributor.authorPortelli, Stephanie
melbourne.contributor.authorKarmakar, Malancha
melbourne.contributor.authorNguyen, Thanh-Binh
dc.identifier.eissn1362-4962
melbourne.identifier.fundernameidNHMRC, 1174405
melbourne.accessrightsOpen Access


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