Transcriptional Memory-Like Imprints and Enhanced Functional Activity in gamma delta T Cells Following Resolution of Malaria Infection
AuthorKumarasingha, R; Ioannidis, LJ; Abeysekera, W; Studniberg, S; Wijesurendra, D; Mazhari, R; Poole, DP; Mueller, I; Schofield, L; Hansen, DS; ...
Source TitleFrontiers in Immunology
PublisherFRONTIERS MEDIA SA
AffiliationMedical Biology (W.E.H.I.)
Anatomy and Neuroscience
Document TypeJournal Article
CitationsKumarasingha, R., Ioannidis, L. J., Abeysekera, W., Studniberg, S., Wijesurendra, D., Mazhari, R., Poole, D. P., Mueller, I., Schofield, L., Hansen, D. S. & Eriksson, E. M. (2020). Transcriptional Memory-Like Imprints and Enhanced Functional Activity in gamma delta T Cells Following Resolution of Malaria Infection. FRONTIERS IN IMMUNOLOGY, 11, https://doi.org/10.3389/fimmu.2020.582358.
Access StatusOpen Access
γδ T cells play an essential role in the immune response to many pathogens, including Plasmodium. However, long-lasting effects of infection on the γδ T cell population still remain inadequately understood. This study focused on assessing molecular and functional changes that persist in the γδ T cell population following resolution of malaria infection. We investigated transcriptional changes and memory-like functional capacity of malaria pre-exposed γδ T cells using a Plasmodium chabaudi infection model. We show that multiple genes associated with effector function (chemokines, cytokines and cytotoxicity) and antigen-presentation were upregulated in P. chabaudi-exposed γδ T cells compared to γδ T cells from naïve mice. This transcriptional profile was positively correlated with profiles observed in conventional memory CD8+ T cells and was accompanied by enhanced reactivation upon secondary encounter with Plasmodium-infected red blood cells in vitro. Collectively our data demonstrate that Plasmodium exposure result in "memory-like imprints" in the γδ T cell population and also promotes γδ T cells that can support antigen-presentation during subsequent infections.
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