MYC in Brain Development and Cancer.

Download
Citations
Altmetric
Author
Zaytseva, O; Kim, N-H; Quinn, LMDate
2020-10-20Source Title
International Journal of Molecular SciencesPublisher
MDPI AGUniversity of Melbourne Author/s
Quinn, LeonieAffiliation
Anatomy and NeuroscienceMetadata
Show full item recordDocument Type
Journal ArticleCitations
Zaytseva, O., Kim, N. -H. & Quinn, L. M. (2020). MYC in Brain Development and Cancer.. Int J Mol Sci, 21 (20), pp.1-14. https://doi.org/10.3390/ijms21207742.Access Status
Open AccessOpen Access at PMC
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588885Abstract
The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC's capacity to promote programs of proliferative cell growth, MYC is frequently upregulated in cancer. Although members of the MYC family are upregulated in nervous system tumours, the mechanisms of how elevated MYC promotes stem cell-driven brain cancers is unknown. If we are to determine how increased MYC might contribute to brain cancer progression, we will require a more complete understanding of MYC's roles during normal brain development. Here, we evaluate evidence for MYC family functions in neural stem cell fate and brain development, with a view to better understand mechanisms of MYC-driven neural malignancies.
Export Reference in RIS Format
Endnote
- Click on "Export Reference in RIS Format" and choose "open with... Endnote".
Refworks
- Click on "Export Reference in RIS Format". Login to Refworks, go to References => Import References