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    MYC in Brain Development and Cancer.

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    Author
    Zaytseva, O; Kim, N-H; Quinn, LM
    Date
    2020-10-20
    Source Title
    International Journal of Molecular Sciences
    Publisher
    MDPI AG
    University of Melbourne Author/s
    Quinn, Leonie
    Affiliation
    Anatomy and Neuroscience
    Metadata
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    Document Type
    Journal Article
    Citations
    Zaytseva, O., Kim, N. -H. & Quinn, L. M. (2020). MYC in Brain Development and Cancer.. Int J Mol Sci, 21 (20), pp.1-14. https://doi.org/10.3390/ijms21207742.
    Access Status
    Open Access
    URI
    http://hdl.handle.net/11343/252661
    DOI
    10.3390/ijms21207742
    Open Access at PMC
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7588885
    Abstract
    The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC's capacity to promote programs of proliferative cell growth, MYC is frequently upregulated in cancer. Although members of the MYC family are upregulated in nervous system tumours, the mechanisms of how elevated MYC promotes stem cell-driven brain cancers is unknown. If we are to determine how increased MYC might contribute to brain cancer progression, we will require a more complete understanding of MYC's roles during normal brain development. Here, we evaluate evidence for MYC family functions in neural stem cell fate and brain development, with a view to better understand mechanisms of MYC-driven neural malignancies.

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